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J Appl Physiol 93: 2044-2052, 2002. First published August 30, 2002; doi:10.1152/japplphysiol.00492.2002
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Vol. 93, Issue 6, 2044-2052, December 2002

Effect of gravity and posture on lung mechanics

D. Bettinelli1, C. Kays2, O. Bailliart3, A. Capderou4, P. Techoueyres2, J. L. Lachaud2, P. Vaïda2, and G. Miserocchi1

1 Dipartimento di Medicina Sperimentale, Ambientale e Biotecnologie Mediche, Università di Milano-Bicocca, I-20052 Monza (MI), Italy; 2 Médecine Aerospatiale, Université de Bordeaux, F-33076 Bordeaux; 4 Centre Chirurgical Marie Lannelougue, UPRES EA2397, Université Paris XI, F-92350 Le Plessis Robinson; and 3 Hôpital Lariboisière, F-75010 Paris, France

The volume-pressure relationship of the lung was studied in six subjects on changing the gravity vector during parabolic flights and body posture. Lung recoil pressure decreased by ~2.7 cmH2O going from 1 to 0 vertical acceleration (Gz), whereas it increased by ~3.5 cmH2O in 30° tilted head-up and supine postures. No substantial change was found going from 1 to 1.8 Gz. Matching the changes in volume-pressure relationships of the lung and chest wall (previous data), results in a decrease in functional respiratory capacity of ~580 ml at 0 Gz relative to 1 Gz and of ~1,200 ml going to supine posture. Microgravity causes a decrease in lung and chest wall recoil pressures as it removes most of the distortion of lung parenchyma and thorax induced by changing gravity field and/or posture. Hypergravity does not greatly affect respiratory mechanics, suggesting that mechanical distortion is close to maximum already at 1 Gz. The end-expiratory volume during quiet breathing corresponds to the mechanical functional residual capacity in each condition.

lung compliance; esophageal pressure; functional residual capacity; interstitial pressure


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