| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Humboldt State University, Arcata, California 95521; and 2 Center for Exercise Science, College of Health and Human Performance, University of Florida, Gainesville, Florida 32611
Previous studies have increased antioxidant capacity in skeletal muscle to attenuate oxidative stress and muscle atrophy during limb immobilization (Appell HJ, Duarte JAR, and Soares JMC. Int J Sports Med 18: 157-160, 1997; Kondo H, Miura M, Nakagaki I, Sasaki S, and Itokawa Y. Am J Physiol Endocrinol Metab 262: E583-E590, 1992). The purpose of this study was to determine the level of oxidative stress in muscle during hindlimb unweighting (HLU) and whether antioxidant supplementation can attenuate the atrophy and changes in contractile properties resulting from 14 days of unweighting. Muscle unweighting caused a 44% decrease in soleus (Sol) and a 30% decrease in gastrocnemius (GS) mass, a 7% decrease in body weight, and 28% decrease in tetanic force in the GS. Protein carbonyls increased by 44% in the Sol with HLU. Antioxidant supplementation did not attenuate the GS or Sol atrophy or the decrease in GS force generation during HLU. Sol and GS protein concentration was not different between groups. The GS was also subjected to three different oxidative challenges to determine whether the supplement increased the antioxidant capacity of the muscle. In all cases, muscles exhibited an increased antioxidant capacity. These data indicate that antioxidant supplementation was not an effective countermeasure to the atrophy associated with HLU.
hindlimb unweighting; oxidative stress; muscle wasting
This article has been cited by other articles:
|
|
 |
|
  T. Barker and M. G. Traber Reply from Tyler Barker and Maret G. Traber J. Physiol., January 1, 2008; 586(1): 309 - 310. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yimlamai, S. L. Dodd, S. E. Borst, and S. Park Clenbuterol induces muscle-specific attenuation of atrophy through effects on the ubiquitin-proteasome pathway J Appl Physiol, July 1, 2005; 99(1): 71 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Selsby and S. L. Dodd Heat treatment reduces oxidative stress and protects muscle mass during immobilization Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R134 - R139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Van Gammeren, D. J. Falk, K. C. DeRuisseau, J. E. Sellman, M. Decramer, and S. K. Powers Reloading the Diaphragm Following Mechanical Ventilation Does Not Promote Injury Chest, June 1, 2005; 127(6): 2204 - 2210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sugiura, N. Abe, M. Nagano, K. Goto, K. Sakuma, H. Naito, T. Yoshioka, and S. K. Powers Changes in PKB/Akt and calcineurin signaling during recovery in atrophied soleus muscle induced by unloading Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1273 - R1278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Leeuwenburgh, C. M. Gurley, B. A. Strotman, and E. E. Dupont-Versteegden Age-related differences in apoptosis with disuse atrophy in soleus muscle Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1288 - R1296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Powers, A. N. Kavazis, and K. C. DeRuisseau Mechanisms of disuse muscle atrophy: role of oxidative stress Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R337 - R344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. Durham, Y.-P. Li, E. Gerken, M. Farid, S. Arbogast, R. R. Wolfe, and M. B. Reid Fatiguing exercise reduces DNA binding activity of NF-{kappa}B in skeletal muscle nuclei J Appl Physiol, November 1, 2004; 97(5): 1740 - 1745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Vassilakopoulos and B. J. Petrof Ventilator-induced Diaphragmatic Dysfunction Am. J. Respir. Crit. Care Med., February 1, 2004; 169(3): 336 - 341. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
