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J Appl Physiol 93: 1893-1899, 2002. First published August 9, 2002; doi:10.1152/japplphysiol.01064.2001
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Vol. 93, Issue 6, 1893-1899, December 2002

Effects of microgravity elicited by parabolic flight on abdominal aortic pressure and heart rate in rats

Hidefumi Waki1, Tsuyoshi Shimizu1, Kiyoaki Katahira2, Tadanori Nagayama1, Masao Yamasaki1, and Shin-Ichiro Katsuda1

1 Department of Physiology, and 2 Experimental Animal Center, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan

Abdominal aortic pressure (AAP), heart rate (HR), and aortic nerve activity (ANA) during parabolic flight were measured by using a telemetry system to clarify the acute effect of microgravity (µG) on hemodynamics in rats. While the animals were conscious, AAP increased up to 119 ± 3 mmHg on exposure to µG compared with the value at 1 G (95 ± 3 mmHg; P < 0.001), whereas AAP decreased immediately on exposure to µG under urethane anesthesia (µG: 72 ± 9 mmHg vs. 1 G: 78 ± 8 mmHg; P < 0.05). HR also increased during µG in conscious animals (µG: 349 ± 12 beats/min vs. 1 G: 324+9 beats/min; P < 0.01), although no change was observed under anesthesia. ANA, which was measured under anesthesia, decreased in response to acute µG exposure (µG: 33 ± 7 counts/s vs. 1 G: 49 ± 5 counts/s; P < 0.01). These results suggest that µG essentially induces a decrease of arterial pressure; however, emotional stress and body movements affect the responses of arterial pressure and HR during exposure to acute µG.

telemetry; arterial pressure; aortic nerve activity


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