Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 93: 1869-1874, 2002. First published August 2, 2002; doi:10.1152/japplphysiol.00252.2002
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
93/5/1869    most recent
00252.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (13)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ware, L. B.
Right arrow Articles by Matthay, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ware, L. B.
Right arrow Articles by Matthay, M. A.
Vol. 93, Issue 5, 1869-1874, November 2002

HIGHLIGHTED TOPICS
Lung Edema Clearance: 20 Years of Progress
Selected Contribution: Mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung

Lorraine B. Ware1, Xiohui Fang2, Yibing Wang2, Tsutomu Sakuma3, Timothy S. Hall4, and Michael A. Matthay2,5

1 Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2650; 2 Cardiovascular Research Institute, University of California, San Francisco, California 94143-0130; 3 Thoracic Surgery, Kanazawa Medical University, Kanazawa, Japan 920-02; 4 Department of Surgery and Cardiothoracic Transplantation 94143, and 5 Departments of Medicine and Anesthesia, University of California, San Francisco, California 94143-0624

Pulmonary edema is common in organ donors and lung transplant recipients. Therefore, we assessed the responsiveness of human donor lungs to pharmacological agents that stimulate clearance of alveolar edema. Organ donors whose lungs were rejected for transplantation were studied. After resection, transport (4°C), and rewarming (37°C) of lungs, alveolar fluid clearance was measured with (n = 8 donors) or without (n = 23 donors) beta -adrenergic stimulation. Terbutaline-stimulated clearance (10-4 M) was higher than unstimulated clearance (7.1 ± 1.3 vs. 4.8 ± 2.4%/h, P < 0.01). Second, we determined whether medications given to the organ donor were associated with the extent of pulmonary edema or the rate of alveolar fluid clearance in the harvested lung. Preharvest administration of dopamine in low to moderate doses was associated with faster alveolar fluid clearance (r = 0.62, P < 0.01). Preharvest administration of diuretics was associated with lower extravascular lung water-to-dry weight ratios. This study provides the first evidence that a beta 2-adrenergic agonist stimulates alveolar fluid clearance in the human donor lung. Aerosolized beta 2-adrenergic agonists may have therapeutic value for hastening the resolution of alveolar edema during the management of donors before resection of lungs for transplantation or in the posttransplant setting.

pulmonary edema; beta -agonist; alveolar epithelial fluid transport; alveolar epithelium; lung preservation


This article has been cited by other articles:


Home page
 Proc Am Thorac SocHome page
D. Van Raemdonck, A. Neyrinck, G. M. Verleden, L. Dupont, W. Coosemans, H. Decaluwe, G. Decker, P. De Leyn, P. Nafteux, and T. Lerut
Lung Donor Selection and Management
Proceedings of the ATS, January 15, 2009; 6(1): 28 - 38.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. A. Frank, R. Briot, J. W. Lee, A. Ishizaka, T. Uchida, and M. A. Matthay
Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs
Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L52 - L59.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
X. Fang, Y. Song, J. Hirsch, L. J. V. Galietta, N. Pedemonte, R. L. Zemans, G. Dolganov, A. S. Verkman, and M. A. Matthay
Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells
Am J Physiol Lung Cell Mol Physiol, February 1, 2006; 290(2): L242 - L249.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. Mehta, J. Bhattacharya, M. A. Matthay, and A. B. Malik
Integrated control of lung fluid balance
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1081 - L1090.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. de Perrot, W. Weder, G.A. Patterson, and S. Keshavjee
Strategies to increase limited donor resources
Eur. Respir. J., March 1, 2004; 23(3): 477 - 482.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Sugita, P. Ferraro, A. Dagenais, M.-E. Clermont, P. Barbry, R. P. Michel, and Y. Berthiaume
Alveolar Liquid Clearance and Sodium Channel Expression Are Decreased in Transplanted Canine Lungs
Am. J. Respir. Crit. Care Med., May 15, 2003; 167(10): 1440 - 1450.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online