Journal of Applied Physiology Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 93: 1841-1851, 2002; doi:10.1152/japplphysiol.00223.2002
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (41)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Musch, G.
Right arrow Articles by Venegas, J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Musch, G.
Right arrow Articles by Venegas, J. G.
Vol. 93, Issue 5, 1841-1851, November 2002

Topographical distribution of pulmonary perfusion and ventilation, assessed by PET in supine and prone humans

Guido Musch1, J. Dominick H. Layfield1,4, R. Scott Harris2, Marcos F. Vidal Melo1, Tilo Winkler1,5, Ronald J. Callahan3, Alan J. Fischman3, and Jose G. Venegas1

Departments of 1 Anesthesia and Critical Care, 2 Medicine (Pulmonary and Critical Care Unit), and 3 Radiology (Division of Nuclear Medicine), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114; 4 Massachusetts Institute of Technology, Boston, Massachusetts 02139; and 5 Clinic of Anesthesiology and Intensive Care Medicine, University Clinic Carl Gustav Carus, Dresden University of Technology, Dresden 01307, Germany

Using positron emission tomography (PET) and intravenously injected 13N2, we assessed the topographical distribution of pulmonary perfusion (Q) and ventilation (V) in six healthy, spontaneously breathing subjects in the supine and prone position. In this technique, the intrapulmonary distribution of 13N2, measured during a short apnea, is proportional to regional Q. After resumption of breathing, regional specific alveolar V (sVA, ventilation per unit of alveolar gas volume) can be calculated from the tracer washout rate. The PET scanner imaged 15 contiguous, 6-mm-thick, slices of lung. Vertical gradients of Q and sVA were computed by linear regression, and spatial heterogeneity was assessed from the squared coefficient of variation (CV2). Both CV<UP><SUB><A><AC>Q</AC><AC>˙</AC></A></SUB><SUP>2</SUP></UP> and CV<UP><SUB>s<A><AC>V</AC><AC>˙</AC></A><SC>a</SC></SUB><SUP>2</SUP></UP> were corrected for the estimated contribution of random imaging noise. We found that 1) both Q and V had vertical gradients favoring dependent lung regions, 2) vertical gradients were similar in the supine and prone position and explained, on average, 24% of Q heterogeneity and 8% of V heterogeneity, 3) CV<UP><SUB><A><AC>Q</AC><AC>˙</AC></A></SUB><SUP>2</SUP></UP> was similar in the supine and prone position, and 4) CV<UP><SUB>s<A><AC>V</AC><AC>˙</AC></A><SC>a</SC></SUB><SUP>2</SUP></UP> was lower in the prone position. We conclude that, in recumbent, spontaneously breathing humans, 1) vertical gradients favoring dependent lung regions explain a significant fraction of heterogeneity, especially of Q, and 2) although Q does not seem to be systematically more homogeneous in the prone position, differences in individual behaviors may make the prone position advantageous, in terms of V-to-Q matching, in selected subjects.

functional lung imaging; positron emission tomography; gas exchange; heterogeneity; prone position


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
R. S. Harris, T. Winkler, G. Musch, M. F. Vidal Melo, T. Schroeder, N. Tgavalekos, and J. G. Venegas
The prone position results in smaller ventilation defects during bronchoconstriction in asthma
J Appl Physiol, July 1, 2009; 107(1): 266 - 274.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Verbanck, Y. Kerckx, D. Schuermans, C. de Bisschop, H. Guenard, R. Naeije, W. Vincken, and A. Van Muylem
The effect of posture-induced changes in peripheral nitric oxide uptake on exhaled nitric oxide
J Appl Physiol, May 1, 2009; 106(5): 1494 - 1498.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
B. Driehuys, H. E. Moller, Z. I. Cleveland, J. Pollaro, and L. W. Hedlund
Pulmonary Perfusion and Xenon Gas Exchange in Rats: MR Imaging with Intravenous Injection of Hyperpolarized 129Xe
Radiology, April 29, 2009; (2009) 2513081550.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
T. J. Arai, A. C. Henderson, D. J. Dubowitz, D. L. Levin, P. J. Friedman, R. B. Buxton, G. K. Prisk, and S. R. Hopkins
Hypoxic pulmonary vasoconstriction does not contribute to pulmonary blood flow heterogeneity in normoxia in normal supine humans
J Appl Physiol, April 1, 2009; 106(4): 1057 - 1064.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. Campana, J. Kenyon, S. Zhalehdoust-Sani, Y.-S. Tzeng, Y. Sun, M. Albert, and K. R. Lutchen
Probing airway conditions governing ventilation defects in asthma via hyperpolarized MRI image functional modeling
J Appl Physiol, April 1, 2009; 106(4): 1293 - 1300.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Hughes and J. B. West
Point:Counterpoint: Gravity is/is not the major factor determining the distribution of blood flow in the human lung
J Appl Physiol, May 1, 2008; 104(5): 1531 - 1533.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. Musch, G. Bellani, M. F. Vidal Melo, R. S. Harris, T. Winkler, T. Schroeder, and J. G. Venegas
Relation between Shunt, Aeration, and Perfusion in Experimental Acute Lung Injury
Am. J. Respir. Crit. Care Med., February 1, 2008; 177(3): 292 - 300.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. R. Hopkins, A. C. Henderson, D. L. Levin, K. Yamada, T. Arai, R. B. Buxton, and G. K. Prisk
Vertical gradients in regional lung density and perfusion in the supine human lung: the Slinky effect
J Appl Physiol, July 1, 2007; 103(1): 240 - 248.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
N. T. Tgavalekos, G. Musch, R. S. Harris, M. F. Vidal Melo, T. Winkler, T. Schroeder, R. Callahan, K. R. Lutchen, and J. G. Venegas
Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics
Eur. Respir. J., June 1, 2007; 29(6): 1174 - 1181.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. S. Harris and D. P. Schuster
Visualizing lung function with positron emission tomography
J Appl Physiol, January 1, 2007; 102(1): 448 - 458.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. Dehnert, F. Risse, S. Ley, T. A. Kuder, R. Buhmann, M. Puderbach, E. Menold, D. Mereles, H.-U. Kauczor, P. Bartsch, et al.
Magnetic Resonance Imaging of Uneven Pulmonary Perfusion in Hypoxia in Humans
Am. J. Respir. Crit. Care Med., November 15, 2006; 174(10): 1132 - 1138.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. Chon, K. C. Beck, R. L. Larsen, H. Shikata, and E. A. Hoffman
Regional pulmonary blood flow in dogs by 4D-X-ray CT
J Appl Physiol, November 1, 2006; 101(5): 1451 - 1465.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
E. A. Hoffman, B. A. Simon, and G. McLennan
State of the Art. A Structural and Functional Assessment of the Lung via Multidetector-Row Computed Tomography: Phenotyping Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, August 1, 2006; 3(6): 519 - 532.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. S. Harris, T. Winkler, N. Tgavalekos, G. Musch, M. F. V. Melo, T. Schroeder, Y. Chang, and J. G. Venegas
Regional Pulmonary Perfusion, Inflation, and Ventilation Defects in Bronchoconstricted Patients with Asthma
Am. J. Respir. Crit. Care Med., August 1, 2006; 174(3): 245 - 253.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
A. J. Yun, P. Y. Lee, and A. N. Gerber
Integrating systems biology and medical imaging: understanding disease distribution in the lung model.
Am. J. Roentgenol., April 1, 2006; 186(4): 925 - 930.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
M. H. Tawhai, K. S. Burrowes, and E. A. Hoffman
Computational models of structure-function relationships in the pulmonary circulation and their validation
Exp Physiol, March 1, 2006; 91(2): 285 - 293.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
E. A. Hoffman and D. Chon
Computed Tomography Studies of Lung Ventilation and Perfusion
Proceedings of the ATS, December 1, 2005; 2(6): 492 - 498.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
G. Musch and J. G. Venegas
Positron Emission Tomography Imaging of Regional Pulmonary Perfusion and Ventilation
Proceedings of the ATS, December 1, 2005; 2(6): 522 - 527.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. T. Tgavalekos, M. Tawhai, R. S. Harris, G. Mush, M. Vidal-Melo, J. G. Venegas, and K. R. Lutchen
Identifying airways responsible for heterogeneous ventilation and mechanical dysfunction in asthma: an image functional modeling approach
J Appl Physiol, December 1, 2005; 99(6): 2388 - 2397.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. M. Walther, M. J. Johansson, T. Flatebo, A. Nicolaysen, and G. Nicolaysen
Marked differences between prone and supine sheep in effect of PEEP on perfusion distribution in zone II lung
J Appl Physiol, September 1, 2005; 99(3): 909 - 914.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Richter, G. Bellani, R. S. Harris, M. F. V. Melo, T. Winkler, J. G. Venegas, and G. Musch
Effect of Prone Position on Regional Shunt, Aeration, and Perfusion in Experimental Acute Lung Injury
Am. J. Respir. Crit. Care Med., August 15, 2005; 172(4): 480 - 487.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. F. V. Melo, R. S. Harris, J. D. H. Layfield, and J. G. Venegas
Topographic Basis of Bimodal Ventilation-Perfusion Distributions during Bronchoconstriction in Sheep
Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 714 - 721.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
F.-C. Lin, Y.-C. Chen, H.-I. Chang, and S.-C. Chang
Effect of Body Position on Gas Exchange in Patients With Idiopathic Pulmonary Alveolar Proteinosis: No Benefit of Prone Positioning
Chest, March 1, 2005; 127(3): 1058 - 1064.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
M. Dolovich and R. Labiris
Imaging Drug Delivery and Drug Responses in the Lung
Proceedings of the ATS, December 1, 2004; 1(4): 329 - 337.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Peces-Barba, M. J. Rodriguez-Nieto, S. Verbanck, M. Paiva, and N. Gonzalez-Mangado
Lower pulmonary diffusing capacity in the prone vs. supine posture
J Appl Physiol, May 1, 2004; 96(5): 1937 - 1942.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
C. Fink, M. Puderbach, M. Bock, K.-P. Lodemann, I. Zuna, A. Schmahl, S. Delorme, and H.-U. Kauczor
Regional Lung Perfusion: Assessment with Partially Parallel Three-dimensional MR Imaging
Radiology, April 1, 2004; 231(1): 175 - 184.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Petersson, A. Sanchez-Crespo, M. Rohdin, S. Montmerle, S. Nyren, H. Jacobsson, S. A. Larsson, S. G. E. Lindahl, D. Linnarsson, R. W. Glenny, et al.
Physiological evaluation of a new quantitative SPECT method measuring regional ventilation and perfusion
J Appl Physiol, March 1, 2004; 96(3): 1127 - 1136.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
D. P. Schuster, A. Kovacs, J. Garbow, and D. Piwnica-Worms
Recent Advances in Imaging the Lungs of Intact Small Animals
Am. J. Respir. Cell Mol. Biol., February 1, 2004; 30(2): 129 - 138.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. Gisolf, R. Wilders, R. V. Immink, J. J. van Lieshout, and J. M. Karemaker
Tidal volume, cardiac output and functional residual capacity determine end-tidal CO2 transient during standing up in humans
J. Physiol., January 15, 2004; 554(2): 579 - 590.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
M. F. Vidal Melo, D. Layfield, R. S. Harris, K. O'Neill, G. Musch, T. Richter, T. Winkler, A. J. Fischman, and J. G. Venegas
Quantification of Regional Ventilation-Perfusion Ratios with PET
J. Nucl. Med., December 1, 2003; 44(12): 1982 - 1991.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online