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Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California 94720
We examined the effects of
menstrual cycle phase and oral contraceptive (OC) use on peak oxygen
consumption (
O2 peak). Six moderately
active, eumenorrheic women (25.5 ± 1.5 yr) were studied before
and after 4 mo of OC. Subjects were tested during the follicular and
luteal phases before OC and the inactive and high-dose phases after
OC. Before OC, there were no significant differences between
the follicular and luteal phases in any of the variables studied. There
were also no differences between the inactive and high-dose phases.
Dietary composition, exercise patterns, and peak heart rate, minute
ventilation, and respiratory exchange ratio did not change with OC use.
However, OC use significantly (P
0.05) increased body
weight (59.6 ± 2.3 to 61.2 ± 2.6 kg) and fat mass (13.3 ± 1.3 to
14.5 ± 1.3 kg) and decreased
O2 peak (
11%, 2.53 ± 0.21 to 2.25 ± 0.18 l/min). In conclusion,
1) endogenous ovarian steroids have little effect on
O2 peak, but 2) the
exogenous ovarian steroids in OC decrease peak exercise capacity in
moderately physically active young women.
menstrual cycle; sex hormones; oxygen consumption; physical fitness and exertion
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