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J Appl Physiol 93: 1542-1548, 2002; doi:10.1152/japplphysiol.00092.2002
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Vol. 93, Issue 4, 1542-1548, October 2002

HIGHLIGHTED TOPICS
Lung Edema Clearance: 20 Years of Progress
Invited Review: Clearance of lung liquid during the perinatal period

Pierre M. Barker1 and Richard E. Olver2

1 Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599-7220; and 2 Tayside Institute of Child Health, Ninewells Hospital and Medical School, University of Dundee, Scotland DD1 9SY, United Kingdom

At birth, the distal lung epithelium undergoes a profound phenotypic switch from secretion to absorption in the course of adaptation to air breathing. In this review, we describe the developmental regulation of key membrane transport proteins and the way in which epinephrine, oxygen, glucocorticoids, and thyroid hormones interact to bring about this crucial change in function. Evidence from molecular, transgenic, cell culture, and whole lung studies is presented, and the clinical consequences of the failure of the physiological mechanisms that underlie perinatal lung liquid absorption are discussed.

lung liquid; sodium absorption; chloride secretion; epithelial sodium channel; cystic fibrosis transmembrane conductance regulator


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