Journal of Applied Physiology
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J Appl Physiol 93: 1527-1532, 2002; doi:10.1152/japplphysiol.00018.2002
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Vol. 93, Issue 4, 1527-1532, October 2002

HIGHLIGHTED TOPICS
Lung Edema Clearance: 20 Years of Progress
Historical perspectives on lung edema clearance

Edward D. Crandall1 and Richard M. Effros2

1 Will Rogers Institute Pulmonary Research Center, University of Southern California, Los Angeles, California 90033; and 2 Division of Pulmonary and Critical Care Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226

Early studies of fluid transport across the pulmonary epithelium were conducted in intact animals or isolated lungs. Although the location and cells responsible for transport cannot be determined with studies in whole mammalian lungs, such preparations remain indispensable for determining the physiological and clinical relevance of in vitro investigations of cells and their transport proteins. Three different approaches have been used to study transport and exchange between the vascular and air space compartments in intact lungs. Some of the advantages and limitations of these methods are briefly reviewed here.

alveolar; interstitium; transport; epithelium; endothelium


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