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J Appl Physiol 93: 984-989, 2002; doi:10.1152/japplphysiol.00677.2001
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Vol. 93, Issue 3, 984-989, September 2002

L-NAME differentially alters ventilatory behavior in Sprague-Dawley and Brown Norway rats

Shyam Subramanian, Bernadette Erokwu, Fang Han, Thomas E. Dick, and Kingman P. Strohl

Department of Medicine, Case Western Reserve University, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106

Nitric oxide (NO) is a regulating factor in respiration. The question was whether NO synthase (NOS) blockade would affect posthypoxic ventilatory behavior similarly in two rat strains with known differences in steady-state hypoxic and hypercapnic responses and in posthypoxic ventilatory behavior. Ventilatory behavior [respiratory frequency (f) and minute ventilation (VE)] was measured by body plethysmography on unanesthetized, unrestrained adult male Sprague-Dawley (SD; n = 8) and Brown Norway rats (BN; n = 8) at baseline and 1 min after rapid transition to 100% O2 after 5 min of isocapnic hypoxia (10% O2-3% CO2-balance N2). Testing was performed 30 min after intraperitoneal injection of either saline (vehicle) or 100 mg/kg of NG-nitro-L-arginine methyl ester (L-NAME). Resting f and VE increased after L-NAME in both strains, more markedly in SD compared with BN (77 vs. 47% for f, and 42 vs. 16% for VE, respectively; P < 0.05). With vehicle, posthypoxic f and VE decline (Dejours phenomenon) was present only in BN and was absent in SD. With L-NAME, the Dejours phenomena were still present in BN but also were apparent in SD (f: 95.3 vs. 134.4 beats/min at baseline; VE: 66.3 vs. 88.8 ml/min at baseline; P < 0.05). Thus NOS blockade results in a strain-specific alteration in resting ventilation and uncovers the Dejours phenomenon in the SD strain.

hyperoxia; hypoxia; nitric oxide; NG-nitro-L-arginine methyl ester


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