Journal of Applied Physiology
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J Appl Physiol 93: 936-946, 2002. First published May 31, 2002; doi:10.1152/japplphysiol.00104.2002
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Vol. 93, Issue 3, 936-946, September 2002

Serotonergic modulation of respiratory motor output during tadpole development

Richard Kinkead, Olivier Belzile, and Roumiana Gulemetova

Department of Pediatrics, Centre de Recherche, Hôpital Saint-François d'Assise, Laval University, Quebec City, Quebec, Canada G1L 3L5

To test the hypothesis that serotonin (5-hydroxytryptamine; 5-HT)-receptor activation elicits age-dependent changes in respiratory motor output, we compared the effects of 5-HT bath application (5-HT concentration = 0.5-25 µM) onto in vitro brain stem preparations from pre- and postmetamorphic bullfrog tadpoles. Recording of motor output related to gill and lung ventilation showed that 5-HT elicits a dose-dependent depression of gill burst frequency in both groups. In contrast, the lung burst frequency response was stage dependent; an increase in lung burst frequency at low 5-HT concentration (<= 0.5 µM) was observed only in the postmetamorphic group. Higher 5-HT concentrations decreased lung burst frequency in all preparations. Gill burst frequency attenuation is mediated (at least in part) by 5-HT1A-receptor activation in an age-dependent fashion. We conclude that serotonergic modulation of respiratory motor output 1) changes during tadpole development and 2) is distinct for gill and lung ventilation.

rhythm generation; development; control of breathing; Rana catesbeiana; motor control; serotonin; 5-hydroxytryptamine


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