Journal of Applied Physiology
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J Appl Physiol 93: 931-935, 2002. First published May 10, 2002; doi:10.1152/japplphysiol.01271.2001
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Vol. 93, Issue 3, 931-935, September 2002

Differential changes of lung diffusing capacity and tissue volume in hypergravity

Malin Rohdin and Dag Linnarsson

Section of Environmental Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden

In normal gravity, lung diffusing capacity (DLCO) and lung tissue volume (LTV; including pulmonary capillary blood volume) change in concert, for example, during shifts between upright and supine. Accordingly, DLCO and LTV might be expected to decrease together in sitting subjects in hypergravity due to peripheral pooling of blood and reduced central blood volume. Nine sitting subjects in a human centrifuge were exposed to one, two, and three times increased gravity in the head-to-feet direction (Gz+) and rebreathed a gas containing trace amounts of acetylene and carbon monoxide. DLCO was 25.2 ± 2.6, 20.0 ± 2.1, and 16.7 ± 1.7 ml · min-1 · mbar-1 (means ± SE) at 1, 2, and 3 Gz+, respectively (ANOVA P < 0.001). Corresponding values for LTV increased from 541 ± 34 to 677 ± 43, and 756 ± 71 ml (P < 0.001) at 2 and 3 Gz+. Results are compatible with sequestration of blood in the dependent part of the pulmonary circulation just as in the systemic counterpart. DLCO, which under normoxic conditions is mainly determined by its membrane component, decreased despite an increased pulmonary capillary blood volume, most likely as a consequence of a less homogenous distribution of alveolar volume with respect to pulmonary capillary blood volume.

acceleration; cardiac output; G stress; pulmonary capillary blood volume


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