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J Appl Physiol 93: 829-833, 2002; doi:10.1152/japplphysiol.00206.2002
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Vol. 93, Issue 3, 829-833, September 2002

Strenuous but not moderate exercise increases the thrombotic tendency in healthy sedentary male volunteers

Yves Cadroy1, Fabien Pillard2, Kjell S. Sakariassen3, Claire Thalamas4, Bernard Boneu1, and Daniel Riviere2

1 Laboratoire d'Hématologie, Hôpital de Rangueil, 31054 Toulouse Cedex; 2 Laboratoire de Physiologie des Adaptations de l'Organisme à l'Exercice Musculaire et des Activités Posturo-Cinétiques, Centre Hospitalier Universitaire Purpan, 31059 Toulouse Cedex, France; 3 Division of General Physiology, Department of Biology, University of Oslo, 0317 Oslo, Norway; and 4 Centre d'Investigation Clinique, Centre Hospitalier Universitaire Purpan, 31059 Toulouse Cedex, France

We have investigated the effect of moderate and strenuous exercise on experimental arterial thrombus formation in men. Thrombogenesis was measured in 15 sedentary healthy male volunteers at rest or immediately after two standardized exercise tests performed for 30 min on a bicycle ergometer. The exercises were performed at a constant load corresponding to either 50 or 70% maximal oxygen uptake. Thrombus formation was induced ex vivo by exposing a collagen-coated coverslip in a parallel plate perfusion chamber to native nonanticoagulated blood for 3 min. The shear rate at the collagen surface was 2,600 s-1. Platelet and fibrin deposition was quantified by immunoenzymatic methods. The results show that moderate exercise did not affect arterial thrombus formation. In contrast, platelet thrombus formation on collagen was increased on the average by 20% after 30 min at 70% maximal oxygen uptake (P = 0.03). Fibrin deposition on collagen remained unchanged with exercise, regardless of its intensity. Thus, with the use of a clinically relevant human experimental model of thrombosis, the present study suggests that exercise of heavy intensity may increase the risk for arterial thrombogenesis in sedentary young healthy male volunteers.

blood flow; platelets; risk factors


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