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J Appl Physiol 93: 1057-1068, 2002. First published May 24, 2002; doi:10.1152/japplphysiol.00568.2001
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Vol. 93, Issue 3, 1057-1068, September 2002

Sex differences in hepatic gene expression in a rat model of ethanol-induced liver injury

Stasa D. Tadic1,2, Mary S. Elm1,2, Ha-Sheng Li2,4, Gijsberta J. Van Londen3, Vladimir M. Subbotin5, David C. Whitcomb1,2,4, and Patricia K. Eagon1,2

1 Veterans Affairs Medical Center, Pittsburgh 15240; Departments of 2 Medicine and 3 Surgery, and 4 Center for Genomic Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261; and 5 Mirus Corporation, Madison, Wisconsin 53719

Sex differences in susceptibility to alcohol-induced liver injury have been observed in both humans and experimental animal models. Using a standard model of alcohol-induced fatty liver injury and microarray analysis, we have identified differential expression of hepatic genes in both sexes. The genes that exhibit differential expression are of three types: those that are changed only in male rats fed alcohol, those that change in only female rats fed alcohol, and those that change in both sexes, although not always in the same manner. Certain of the differentially expressed genes have previously been identified as participants in the induction of alcohol-induced liver injury. However, this analysis has identified a number of genes that heretofore have not been implicated in alcoholic liver injury; such genes may provide new areas of investigation into the pathogenesis of this disease.

alcohol; microarray analysis


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