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J Appl Physiol 93: 645-648, 2002. First published May 3, 2002; doi:10.1152/japplphysiol.01214.2001
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Vol. 93, Issue 2, 645-648, August 2002

Exercise-induced change in type 1 cytokine-producing CD8+ T cells is related to a decrease in memory T cells

Tobias Ibfelt1,2, Emil Wolsk Petersen1,2, Helle Bruunsgaard1, Marie Sandmand1, and Bente Klarlund Pedersen1,2

1 Department of Infectious Diseases and 2 Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, DK-2200 Copenhagen, Denmark

In response to exercise, both CD4+ and CD8+ T cells are mobilized to the blood, but the levels of these cells decline below preexercise values in the postexercise period. T cells are functionally polarized, depending on the cytokines they produce. Type 1 cells produce, e.g., interferon (INF)-gamma , whereas type 2 produce, e.g., interleukin (IL)-4. It was recently demonstrated that exercise induces a decrease in the percentage of type 1 T cells. The present study further investigated the mechanisms underlying the exercise-induced shift in the balance between type 1 and type 2 cytokine-producing cells. Seven healthy men performed 1.5 h of treadmill running with blood samples drawn before exercise, at the end of exercise, and 2 h after exercise. Intracellular expression of IFN-gamma , IL-2, and IL-4 was detected in CD4+ and CD8+ T cells after stimulation with phorbol 12-myristate 13-acetate and ionomycin. Intracellular expression of IFN-gamma within CD8+ cells was decreased in the postexercise period compared with values obtained immediately after exercise, whereas the expression of IL-2 and IL-4 did not change within the CD4+ and CD8+ cell populations. The decrease in IFN-gamma -producing CD8+ T cells postexercise was negatively correlated with a decrease in percentage of memory T cells within the CD8+ cells (r = -0.94; P <=  0.002). In conclusion, this study demonstrates that the exercise-induced change in type 1 cytokine-producing T cells is related to a decline in memory cells.

intracellular cytokines; type 1/type 2; memory cells


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