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J Appl Physiol 93: 601-610, 2002. First published April 19, 2002; doi:10.1152/japplphysiol.00949.2001
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Vol. 93, Issue 2, 601-610, August 2002

Hypoxemia and low Crs in vagally denervated lambs result from reduced lung volume and not pulmonary edema

Salim Lalani, John E. Remmers, Yolanda MacKinnon, Gordon T. Ford, and Shabih U. Hasan

Department of Pediatrics, Respiratory Research Group, Faculty of Medicine, The University of Calgary, Calgary, Alberta, Canada T2N 4N1

Vagal denervation performed in the intrathoracic region in newborn lambs leads to hypoxemia and decreased respiratory system compliance (Crs), which could result from atelectasis and/or pulmonary edema. The objective of the present study was to quantify the relative roles of alveolar derecruitment and pulmonary edema as underlying cause(s) of respiratory failure. Vagal denervation was performed in the intrathoracic region and below the recurrent laryngeal nerves in six newborn lambs within 24 h of birth, whereas six were sham operated. Pre- and postinflation Crs was measured to investigate the presence of alveolar derecruitment. Pulmonary edema was assessed with lung wet-dry-to-wet and lung tissue wet-to-dry ratios, total protein, and FITC-BSA recovery in lung tissue and bronchoalveolar lavage. Compared with that in the sham-operated animals, Crs was significantly lower in vagally denervated animals. However, postinflation, pulmonary system compliance obtained by quasi-static lung inflation and deflation to 30 cmH2O showed no significant difference between the sham-operated and denervated lambs. The lung wet-dry-to-wet and lung tissue wet-to-dry ratios, total protein, and FITC-BSA recovery in lung tissue and bronchoalveolar lavage were similar in denervated and sham-operated groups. We provide evidence that reduced lung volume and not pulmonary edema is associated with intrathoracic vagal denervation and is the likely underlying mechanism for hypoxemia and low Crs.

arousal; breathing patterns; capillary-alveolar leak; control of breathing; newborn; pulmonary mechanics; vagal afferents


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