Journal of Applied Physiology Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 93: 384-392, 2002; doi:10.1152/japplphysiol.00043.2002
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (34)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wojtaszewski, J. F. P.
Right arrow Articles by Richter, E. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wojtaszewski, J. F. P.
Right arrow Articles by Richter, E. A.
Vol. 93, Issue 1, 384-392, July 2002

HIGHLIGHTED TOPICS
Exercise Effects on Muscle Insulin Signaling and Action
Invited Review: Effect of acute exercise on insulin signaling and action in humans

Jørgen F. P. Wojtaszewski, Jakob N. Nielsen, and Erik A. Richter

Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sports Sciences, University of Copenhagen, Copenhagen 2100, Denmark

After a single bout of exercise, insulin action is increased in the muscles that were active during exercise. The increased insulin action has been shown to involve glucose transport, glycogen synthesis, and glycogen synthase (GS) activation as well as amino acid transport. A major mechanism involved in increased insulin stimulation of glucose uptake after exercise seems to be the exercise-associated decrease in muscle glycogen content. Muscle glycogen content also plays a pivotal role for the activity of GS and for the ability of insulin to increase GS activity. Insulin signaling in human skeletal muscle is activated by physiological insulin concentrations, but the increase in insulin action after exercise does not seem to be related to increased insulin signaling [insulin receptor tyrosine kinase activity, insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation (RS1), IRS-1-associated phosphatidylinositol 3-kinase activity, Akt phosphorylation (Ser473), glycogen synthase kinase 3 (GSK3) phosphorylation (Ser21), and GSK3alpha activity], as measured in muscle lysates. Furthermore, insulin signaling is also largely unaffected by exercise itself. This, however, does not preclude that exercise influences insulin signaling through changes in the spatial arrangement of the signaling compounds or by affecting unidentified signaling intermediates. Finally, 5'-AMP-activated protein kinase has recently entered the stage as a promising player in explaining at least a part of the mechanism by which exercise enhances insulin action.

glycogen synthase; muscle glucose transport; insulin sensitivity; glycogen


This article has been cited by other articles:


Home page
 Diabetes Spectr.Home page
U. G. Bronas, D. Treat-Jacobson, and P. Painter
Alternative Forms of Exercise Training as Complementary Therapy in the Prevention and Management of Type 2 Diabetes
Diabetes Spectr, October 1, 2009; 22(4): 220 - 225.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Hoene, R. Lehmann, A. M. Hennige, A. K. Pohl, H. U. Haring, E. D. Schleicher, and C. Weigert
Acute regulation of metabolic genes and insulin receptor substrates in the liver of mice by one single bout of treadmill exercise
J. Physiol., January 1, 2009; 587(1): 241 - 252.
[Abstract] [Full Text] [PDF]

Home page
 ptjournalHome page
L. P Turcotte and J. S Fisher
Skeletal Muscle Insulin Resistance: Roles of Fatty Acid Metabolism and Exercise
Physical Therapy, November 1, 2008; 88(11): 1279 - 1296.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. P. Thyfault
Setting the stage: possible mechanisms by which acute contraction restores insulin sensitivity in muscle
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1103 - R1110.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. E. Pratt, R. J. Geor, L. L. Spriet, and L. J. McCutcheon
Time course of insulin sensitivity and skeletal muscle glycogen synthase activity after a single bout of exercise in horses
J Appl Physiol, September 1, 2007; 103(3): 1063 - 1069.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. Frosig, M. P. Sajan, S. J. Maarbjerg, N. Brandt, C. Roepstorff, J. F. P. Wojtaszewski, B. Kiens, R. V. Farese, and E. A. Richter
Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle
J. Physiol., August 1, 2007; 582(3): 1289 - 1301.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. R. Ropelle, J. R. Pauli, P. O. Prada, C. T. de Souza, P. K. Picardi, M. C. Faria, D. E. Cintra, M. F. d. A. Fernandes, M. B. Flores, L. A. Velloso, et al.
Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation
J. Physiol., December 15, 2006; 577(3): 997 - 1007.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Hamada, E. B. Arias, and G. D. Cartee
Increased submaximal insulin-stimulated glucose uptake in mouse skeletal muscle after treadmill exercise
J Appl Physiol, November 1, 2006; 101(5): 1368 - 1376.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
O. H. Mortensen, L. Frandsen, P. Schjerling, E. Nishimura, and N. Grunnet
PGC-1{alpha} and PGC-1beta have both similar and distinct effects on myofiber switching toward an oxidative phenotype
Am J Physiol Endocrinol Metab, October 1, 2006; 291(4): E807 - E816.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. Wilson, M. Hargreaves, and K. F. Howlett
Exercise does not alter subcellular localization, but increases phosphorylation of insulin-signaling proteins in human skeletal muscle
Am J Physiol Endocrinol Metab, February 1, 2006; 290(2): E341 - E346.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
Y. Hayashi, S. Nagasaka, N. Takahashi, I. Kusaka, S. Ishibashi, S. Numao, D. J. Lee, Y. Taki, H. Ogata, K. Tokuyama, et al.
A Single Bout of Exercise at Higher Intensity Enhances Glucose Effectiveness in Sedentary Men
J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4035 - 4040.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Teran-Garcia, T. Rankinen, R. A. Koza, D. C. Rao, and C. Bouchard
Endurance training-induced changes in insulin sensitivity and gene expression
Am J Physiol Endocrinol Metab, June 1, 2005; 288(6): E1168 - E1178.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Xiang, J. Naik, and R. L. Hester
Exercise-induced increase in skeletal muscle vasodilatory responses in obese Zucker rats
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R987 - R991.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
R. J. Sigal, G. P. Kenny, D. H. Wasserman, and C. Castaneda-Sceppa
Physical Activity/Exercise and Type 2 Diabetes
Diabetes Care, October 1, 2004; 27(10): 2518 - 2539.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. A. McIntyre, R. Halse, S. J. Yeaman, and M. Walker
Cultured Muscle Cells from Insulin-Resistant Type 2 Diabetes Patients Have Impaired Insulin, but Normal 5-Amino-4-Imidazolecarboxamide Riboside-Stimulated, Glucose Uptake
J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3440 - 3448.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
R. Ross
Does Exercise Without Weight Loss Improve Insulin Sensitivity?
Diabetes Care, March 1, 2003; 26(3): 944 - 945.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. S. Olsen and B. F. Hansen
AMP kinase activation ameliorates insulin resistance induced by free fatty acids in rat skeletal muscle
Am J Physiol Endocrinol Metab, November 1, 2002; 283(5): E965 - E970.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online