Journal of Applied Physiology
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J Appl Physiol 93: 31-36, 2002; doi:10.1152/japplphysiol.00177.2001
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Vol. 93, Issue 1, 31-36, July 2002

Cerebral cortical respiratory-related evoked potentials elicited by inspiratory occlusion in lambs

Paul W. Davenport and Alastair A. Hutchison

Departments of Physiological Sciences and Pediatrics, University of Florida, Gainesville, Florida 32610

Respiratory-related evoked potentials (RREP) elicited by inspiratory mechanical loads have been recorded in humans. Early RREP peaks were hypothesized to be generated by activation of neurons in the somatosensory cortex. An animal model was developed to test this hypothesis in chronically instrumented, awake, spontaneously breathing lambs. Electrocorticogram (ECoG) was recorded bilaterally with ball electrodes on the dural surface over the somatosensory region. Inspiratory occlusions were presented through a face mask or endotracheal tube as interruptions of inspiration. Occlusion-elicited evoked potentials were obtained by computer-signal averaging the ECoG activity. A short-latency positive peak was observed bilaterally in the averaged occlusion-elicited evoked potentials in all animals breathing with the facemask and 5 of 8 lambs with the endotracheal tube. Postmortem identification of the electrode location demonstrated that the ECoG was recorded in the caudal-lateral portion of the somatosensory cortex. These results demonstrate that inspiratory occlusion elicits an evoked potential in the somatosensory cortical region of awake, spontaneously breathing lambs. The lamb cortical RREP is similar to human RREP.

inspiratory load; somatosensory; electrocorticogram


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