Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 93: 31-36, 2002; doi:10.1152/japplphysiol.00177.2001
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Davenport, P. W.
Right arrow Articles by Hutchison, A. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Davenport, P. W.
Right arrow Articles by Hutchison, A. A.
Vol. 93, Issue 1, 31-36, July 2002

Cerebral cortical respiratory-related evoked potentials elicited by inspiratory occlusion in lambs

Paul W. Davenport and Alastair A. Hutchison

Departments of Physiological Sciences and Pediatrics, University of Florida, Gainesville, Florida 32610

Respiratory-related evoked potentials (RREP) elicited by inspiratory mechanical loads have been recorded in humans. Early RREP peaks were hypothesized to be generated by activation of neurons in the somatosensory cortex. An animal model was developed to test this hypothesis in chronically instrumented, awake, spontaneously breathing lambs. Electrocorticogram (ECoG) was recorded bilaterally with ball electrodes on the dural surface over the somatosensory region. Inspiratory occlusions were presented through a face mask or endotracheal tube as interruptions of inspiration. Occlusion-elicited evoked potentials were obtained by computer-signal averaging the ECoG activity. A short-latency positive peak was observed bilaterally in the averaged occlusion-elicited evoked potentials in all animals breathing with the facemask and 5 of 8 lambs with the endotracheal tube. Postmortem identification of the electrode location demonstrated that the ECoG was recorded in the caudal-lateral portion of the somatosensory cortex. These results demonstrate that inspiratory occlusion elicits an evoked potential in the somatosensory cortical region of awake, spontaneously breathing lambs. The lamb cortical RREP is similar to human RREP.

inspiratory load; somatosensory; electrocorticogram


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
Y. L. Chou and P. W. Davenport
The effect of increased background resistance on the resistive load threshold for eliciting the respiratory-related evoked potential
J Appl Physiol, December 1, 2007; 103(6): 2012 - 2017.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
D. E. O'Donnell, R. B. Banzett, V. Carrieri-Kohlman, R. Casaburi, P. W. Davenport, S. C. Gandevia, A. F. Gelb, D. A. Mahler, and K. A. Webb
Pathophysiology of Dyspnea in Chronic Obstructive Pulmonary Disease: A Roundtable
Proceedings of the ATS, May 1, 2007; 4(2): 145 - 168.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. W. Davenport, P.-Y. S. Chan, W. Zhang, and Y.-L. Chou
Detection threshold for inspiratory resistive loads and respiratory-related evoked potentials
J Appl Physiol, January 1, 2007; 102(1): 276 - 285.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. Zhang and P. W. Davenport
Activation of thalamic ventroposteriolateral neurons by phrenic nerve afferents in cats and rats
J Appl Physiol, January 1, 2003; 94(1): 220 - 226.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Gora, J. Trinder, R. Pierce, and I. M. Colrain
Evidence of a Sleep-Specific Blunted Cortical Response to Inspiratory Occlusions in Mild Obstructive Sleep Apnea Syndrome
Am. J. Respir. Crit. Care Med., November 1, 2002; 166(9): 1225 - 1234.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online