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J Appl Physiol 93: 207-215, 2002; doi:10.1152/japplphysiol.01151.2001
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Vol. 93, Issue 1, 207-215, July 2002

Elevated IL-1beta contributes to antibody suppression produced by stress

Albert Moraska1, Jay Campisi1,3, Kien T. Nguyen4, Steven F. Maier2,3, Linda R. Watkins2,3, and Monika Fleshner1,3

1 Department of Kinesiology and Applied Physiology, 2 Department of Psychology, and 3 Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309; and 4 Ethicon, Somerville, New Jersey 08876

Acute stressor exposure can facilitate innate immunity and suppress acquired immunity. The present study further characterized the potentiating effect of stress on innate immunity, interleukin-1beta (IL-1beta ), and demonstrated that stress-induced potentiation of innate immunity may contribute to the stress-induced suppression of acquired immunity. The long-term effect of stress on IL-1beta was measured by using an ex vivo approach. Sprague-Dawley rats were challenged with lipopolysaccharide (LPS) in vivo, and the IL-1beta response was measured in vitro. Splenocytes, mesenteric lymphocytes, and peritoneal cavity cells had a dose- and time-dependent ex vivo IL-1beta response to LPS. Rats that were exposed to inescapable shock (IS, 100 1.6 mA, 5-s tail shocks, 60-s intertrial interval) and challenged with a submaximal dose of LPS 4 days later had elevated IL-1beta measured ex vivo. To test whether the acute stress-induced elevation in IL-1beta contributes to the long-term suppression in acquired immunity, IL-1beta receptors were blocked for 24 h after stress. Serum anti-keyhole limpet hemocyanin (KLH) immunoglobulin (Ig) was measured. In addition, the acute elevation (2 h post-IS) of splenic IL-1beta in the absence of antigen was verified. Interleukin-1 receptor antagonist prevented IS-induced suppression in anti-KLH Ig. These data support the hypothesis that stress-induced increases in innate immunity (i.e., IL-1beta ) may contribute to stress-induced suppression in acquired immunity (i.e., anti-KLH Ig).

interleukin-1beta ; interleukin-1 receptor antagonist; keyhole limpet hemocyanin; lipopolysaccharide


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