Journal of Applied Physiology
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J Appl Physiol 93: 134-140, 2002. First published March 15, 2002; doi:10.1152/japplphysiol.00421.2001
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Vol. 93, Issue 1, 134-140, July 2002

Elevation in resting blood flow attenuates exercise hyperemia

Zoran Valic, Jay S. Naik, Stephen B. Ruble, John B. Buckwalter, and Philip S. Clifford

Departments of Anesthesiology and Physiology, Medical College of Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295

These experiments tested the hypothesis that elevating muscle blood flow before exercise would wash out vasoactive substances produced by muscle contraction and reduce the magnitude of exercise hyperemia and/or delay the response. In chronically instrumented dogs (n = 7), hindlimb blood flow was measured with chronically implanted flow probes during mild treadmill exercise. In an anesthetized preparation (n = 8), arterial and venous blood flows of a single hindlimb were obtained during 1-s tetanic contractions evoked by electrical stimulation of the cut sciatic nerve. Elevation of blood flow by intra-arterial infusion of adenosine attenuated the increase in flow during exercise and tetanic contraction by 48 and 47%, respectively. No delay was observed in the latency to peak flow. The attenuated hyperemic response to exercise or contraction is best explained by washout of vasoactive substance(s) produced by contracting muscle, but the residual response suggests that a metabolic mediator may not be the sole explanation for exercise hyperemia.

skeletal muscle; vasodilation; tetanic contractions; muscle pump; dog


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