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J Appl Physiol 92: 2640-2647, 2002; doi:10.1152/japplphysiol.01007.2001
8750-7587/02 $5.00
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Vol. 92, Issue 6, 2640-2647, June 2002

HIGHLIGHTED TOPICS
Molecular Biology of Thermoregulation
Invited Review: Molecular adaptations in mammalian hibernators: unique adaptations or generalized responses?

Frank van Breukelen and Sandra L. Martin

Department of Cellular and Structural Biology, University of Colorado School of Medicine, Denver, Colorado 80262

Hibernators are unique among mammals in their ability to attain, withstand, and reverse low body temperatures. Hibernators repeatedly cycle between body temperatures near zero during torpor and 37°C during euthermy. How do these mammals maintain cardiac function, cell integrity, blood fluidity, and energetic balance during their prolonged periods at low body temperature and avoid damage when they rewarm? Hibernation is often considered an example of a unique adaptation for low-temperature function in mammals. Although such adaptation is apparent at the level of whole animal physiology, it is surprisingly difficult to demonstrate clear examples of adaptations at the cellular and biochemical levels that improve function in the cold and are unique to hibernators. Instead of adaptation for improved function in the cold, the key molecular adaptations of hibernation may be to exploit the cold to depress most aspects of biochemical function and then rewarm without damage to restore optimal function of all systems. These capabilities are likely due to novel regulation of biochemical pathways shared by all mammals, including humans.

torpor; hypothermia; differential gene expression


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