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1 Department of Animal Health and Biomedical Sciences and 2 Medical Scientist Training Program, University of Wisconsin, Madison, Wisconsin 53706
The hypothesis that the
accumulation of electron transport system (ETS) abnormalities and
sarcopenia are linked was investigated. Vastus lateralis, soleus, and
adductor longus muscles were studied in 5-, 18-, and 36-mo-old male
Fischer 344 × Brown Norway F1 hybrid rats. A
significant decrease in soleus and vastus lateralis muscle mass was
observed with age. Adductor longus was resistant to muscle mass loss.
Multiple serial sections were analyzed for the activities of
cytochrome-c oxidase (COX) and succinate dehydrogenase
(SDH). The number of fibers exhibiting a
COX
/SDH++ phenotype increased with age in
both vastus lateralis and soleus muscles. No ETS-abnormal fibers were
identified in adductor longus at any age. Cross-sectional area of
ETS-abnormal fibers decreased in the abnormal region (region displaying
COX/SDH++ phenotype), whereas control fibers
did not. The vastus lateralis muscle, which undergoes a high degree of
sarcopenia, exhibited more ETS abnormalities and associated fiber loss
than the soleus and adductor longus muscles, which are more resistant
to sarcopenia, suggesting a direct association between ETS
abnormalities and fiber loss.
aging; ragged red fiber; rat; muscle atrophy
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