Journal of Applied Physiology AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 92: 2600-2607, 2002; doi:10.1152/japplphysiol.01008.2001
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fleming, S. d.
Right arrow Articles by Shea-Donohue, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fleming, S. d.
Right arrow Articles by Shea-Donohue, T.
Vol. 92, Issue 6, 2600-2607, June 2002

Heat stress protection against mesenteric I/R-induced alterations in intestinal mucosa in rats

Sherry d. Fleming1,4, Benjamin W. Starnes2,3, Juliann G. Kiang1,4,5, Alexander Stojadinovic2,3, George C. Tsokos1,2,4, and Terez Shea-Donohue4,6

1 Department of Cellular Injury, Walter Reed Army Medical Institute of Research, Silver Spring, Maryland; 2 Department of Surgery, Walter Reed Army Medical Center, Washington, DC 20307; Departments of 3 Surgery, 4 Medicine, and 5 Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814; and 6 Beltsville Agricultural Research Center, Nutrient Requirements and Function Laboratory, Beltsville, Maryland 20705

Prior induction of heat shock protein 70 (HSP70) protects against ischemia-reperfusion (I/R) mucosal injury, but the ability of HSP70 to affect I/R-induced alterations in epithelial cell function is unknown. Rats subjected to whole body hyperthermia (41.5-42°C for 6 min) increased HSP70 and heat shock factor 1 mRNA expression, reaching a maximum 2 h after heat stress and declining thereafter. HSP70 production was maximally elevated at 4 h after heat stress and remained elevated until after 12 h. Heat stress alone had no effect on mucosal function except to enhance secretion in response to ACh. Heat stress provided complete morphological protection against I/R-induced mucosal injury but did not confer a similar protection against I/R-induced decreases in mucosal resistance, sodium-linked glucose absorption, or tachykinin-mediated chloride secretion. Heat stress, however, attenuated the I/R-induced suppression of ACh response, and this effect was dependent on enteric nerves. Thus induction of heat shock protein 70 is associated with the preservation of mucosal architecture and attenuation of some specific functional alterations induced by I/R.

heat shock; intestinal function; ischemia-reperfusion


This article has been cited by other articles:


Home page
 J. Nutr.Home page
H. Xue, M. B. Sawyer, C. J. Field, L. A. Dieleman, D. Murray, and V. E. Baracos
Bolus Oral Glutamine Protects Rats against CPT-11-Induced Diarrhea and Differentially Activates Cytoprotective Mechanisms in Host Intestine but Not Tumor
J. Nutr., April 1, 2008; 138(4): 740 - 746.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. G. Kiang, P. D. Bowman, B. W. Wu, N. Hampton, A. G. Kiang, B. Zhao, Y.-T. Juang, J. L. Atkins, and G. C. Tsokos
Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70
J Appl Physiol, August 1, 2004; 97(2): 564 - 569.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online