Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 92: 2452-2456, 2002. First published February 22, 2002; doi:10.1152/japplphysiol.01243.2001
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
92/6/2452    most recent
01243.2001v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hamann, J. J.
Right arrow Articles by Clifford, P. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hamann, J. J.
Right arrow Articles by Clifford, P. S.
Vol. 92, Issue 6, 2452-2456, June 2002

Sympathetic restraint of muscle blood flow at the onset of dynamic exercise

Jason J. Hamann, John B. Buckwalter, Zoran Valic, and Philip S. Clifford

Departments of Anesthesiology and Physiology, Medical College of Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295

Little attention has focused on sympathetic influences on skeletal muscle blood flow at the onset of exercise. We hypothesized that 1) the sympathetic nervous system constrains muscle blood flow and 2) the decline from peak blood flow is mediated by increasing sympathetic vasoconstrictor tone. Mongrel dogs (n = 7) ran on a treadmill after intra-arterial infusion of saline (control) or combined alpha 1- and alpha 2-adrenergic blockade (prazosin and rauwolscine). Immediate and rapid increases in hindlimb blood flow occurred at commencement of exercise with peak iliac blood flows averaging 933 ± 79 and 1,227 ± 90 ml/min during control and blockade conditions, respectively. At 1 min of exercise, hindlimb blood flow had decreased to 629 ± 54 and 1,057 ± 89 ml/min. In the absence of sympathetic vasoconstrictor tone, there was an enhanced peak blood flow at the onset of exercise. In addition, alpha -blockade attenuated the overshoot of hindlimb blood flow compared with the control condition. These data suggest that an immediate and sustained increase in sympathetic outflow restrains hindlimb blood flow at the onset of exercise and is responsible, at least in part, for an overshoot of blood flow to exercising skeletal muscle.

hyperemia; autonomic; adrenergic receptors


This article has been cited by other articles:


Home page
 J. Physiol.Home page
J. C. Taylor, Z. Li, H. T. Yang, M. H. Laughlin, and R. L. Terjung
{alpha}-Adrenergic inhibition increases collateral circuit conductance in rats following acute occlusion of the femoral artery
J. Physiol., March 15, 2008; 586(6): 1649 - 1667.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. S. DeLorey, J. J. Hamann, Z. Valic, H. A. Kluess, P. S. Clifford, and J. B. Buckwalter
{alpha}-Adrenergic receptor responsiveness is preserved during prolonged exercise
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H392 - H398.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. S. DeLorey, J. J. Hamann, H. A. Kluess, P. S. Clifford, and J. B. Buckwalter
{alpha}-Adrenergic receptor-mediated restraint of skeletal muscle blood flow during prolonged exercise
J Appl Physiol, May 1, 2006; 100(5): 1563 - 1568.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Koba, T. Yoshida, and N. Hayashi
Differential sympathetic outflow and vasoconstriction responses at kidney and skeletal muscles during fictive locomotion
Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H861 - H868.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. B. Buckwalter, J. J. Hamann, and P. S. Clifford
Neuropeptide Y1 receptor vasoconstriction in exercising canine skeletal muscles
J Appl Physiol, December 1, 2005; 99(6): 2115 - 2120.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. C. Frisbee
Enhanced arteriolar {alpha}-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats
J Appl Physiol, August 1, 2004; 97(2): 764 - 772.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. S. Clifford and Y. Hellsten
Vasodilatory mechanisms in contracting skeletal muscle
J Appl Physiol, July 1, 2004; 97(1): 393 - 403.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. B. Buckwalter, J. J. Hamann, H. A. Kluess, and P. S. Clifford
Vasoconstriction in exercising skeletal muscles: a potential role for neuropeptide Y?
Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H144 - H149.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. B. Buckwalter, J. C. Taylor, J. J. Hamann, and P. S. Clifford
Do P2X purinergic receptors regulate skeletal muscle blood flow during exercise?
Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H633 - H639.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. B. Buckwalter, J. J. Hamann, and P. S. Clifford
Vasoconstriction in active skeletal muscles: a potential role for P2X purinergic receptors?
J Appl Physiol, September 1, 2003; 95(3): 953 - 959.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online