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Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, Nebraska 68198-4575
Moderate exercise training
(Ex) enhances work capacity and quality of life in patients with
chronic heart failure (CHF). We investigated the autonomic
components of resting heart rate (HR) and the baroreflex control of HR
in conscious, instrumented rabbits with pacing-induced CHF after Ex.
Sham and CHF rabbits were exercise trained for 4 wk at 15-18
m/min, 6 days/wk. Arterial pressure and HR were recorded before and
after metoprolol (1 mg/kg iv) or after atropine (0.2 mg/kg iv). Mean
arterial pressure was altered by infusions of sodium nitroprusside and
phenylephrine. The data were fit to a sigmoid (logistic) function.
Baseline HRs were 266.5 ± 8.4 and 232.1 ± 1.6 beats/min in
CHF and CHF Ex rabbits, respectively (P < 0.05). In
the unblocked state, CHF rabbits had a significantly depressed peak
baroreflex slope (1.7 ± 0.3 vs. 5.6 ± 0.7 beats · min
1 · mmHg1;
P < 0.001) and HR range (128.6 ± 34.5 vs.
253.2 ± 20.3 beats/min; P < 0.05) compared with
normal subjects. Ex increased baroreflex slope to 4.9 ± 0.3 from
1.7 ± 0.3 beats · min1 · mmHg1 in
unblocked rabbits (P < 0.001 compared with CHF
non-Ex). Ex did not alter baroreflex function in sham animals. After
metoprolol, baroreflex slope was significantly increased in CHF Ex
rabbits (1.5 ± 0.2 vs. 3.0 ± 0.2 beats · min1 · mmHg1;
P < 0.05). After atropine, there was no significant
change in baroreflex slope or HR range between CHF Ex and CHF rabbits.
These data support the view that enhancement of baroreflex control of HR after Ex is due to an augmentation of vagal tone.
autonomic regulation; vagus
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