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J Appl Physiol 92: 2353-2360, 2002. First published February 22, 2002; doi:10.1152/japplphysiol.01248.2001
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Vol. 92, Issue 6, 2353-2360, June 2002

Exercise-induced bronchodilation in natural and induced asthma: effects on ventilatory response and performance

Emanuele Crimi, Riccardo Pellegrino, Attilio Smeraldi, and Vito Brusasco

Dipartimenti di Medicina Interna e di Scienze Motorie e Riabilitative, Università di Genova, 16132 Genova; and Fisiopatologia Respiratoria, Azienda Ospedaliera S. Croce e Carle, 12100 Cuneo, Italy

We studied whether bronchodilatation occurs with exercise during the late asthmatic reaction (LAR) to allergen (group 1, n = 13) or natural asthma (NA; group 2, n = 8) and whether this is sufficient to preserve maximum ventilation (VEmax), oxygen consumption (VO2 max), and exercise performance (Wmax). In group 1, partial forced expiratory flow at 30% of resting forced vital capacity increased during exercise, both at control and LAR. Wmax was slightly reduced at LAR, whereas VEmax, tidal volume, breathing frequency, and VO2 max were preserved. Functional residual capacity and end-inspiratory lung volume were significantly larger at LAR than at control. In group 2, partial forced expiratory flow at 30% of resting forced vital capacity increased greatly with exercise during NA but did not attain control values after appropriate therapy. Compared with control, Wmax was slightly less during NA, whereas VO2 max and VEmax were similar. Functional residual capacity, but not end-inspiratory lung volume at maximum load, was significantly greater than at control, whereas tidal volume decreased and breathing frequency increased. In conclusion, remarkable exercise bronchodilation occurs during either LAR or NA and allows VEmax and VO2 max to be preserved with small changes in breathing pattern and a slight reduction in Wmax.

incremental exercise; natural asthma; late asthmatic reaction; deep inhalation; breathing pattern


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