Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 92: 2162-2168, 2002. First published January 4, 2002; doi:10.1152/japplphysiol.01192.2001
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
92/5/2162    most recent
01192.2001v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (13)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wang, H.-J.
Right arrow Articles by Yao, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, H.-J.
Right arrow Articles by Yao, T.
Vol. 92, Issue 5, 2162-2168, May 2002

Effects of all-trans retinoic acid on angiotensin II-induced myocyte hypertrophy

Hao-Jie Wang, Yi-Chun Zhu, and Tai Yao

Kidney and Hypertension Research Center, Department of Physiology, Medical Center of Fudan University, Shanghai 200032, People's Republic of China

We used cultured neonatal rat cardiac myocytes to test the hypothesis that all-trans retinoic acid (atRA) may act to modulate ANG II actions in inducing myocyte hypertrophy. Our observations were as follows. 1) atRA (10-7 to ~10-5 M ) inhibited ANG II-induced hyperplasia of fibroblasts in a dose-dependent manner. 2) Treatment of atRA attenuated the ANG II-induced increase in total cell protein content. 3) Treated with ANG II (10-7 M) for 5 days, the cultured neonatal rat cardiac myocytes demonstrated an apparent accumulation of sarcomeric fiber proteins and Golgi's complex, as well as reorganization of the sarcomeric unit within individual myocytes. atRA (10-6 M) treatment reduced the accumulation of contractile proteins and Golgi's complex without affecting the ANG II-induced reorganization of the sarcomeric unit. 4) atRA attenuated the ANG II-induced increase in intracellular Ca2+. Our results show that atRA inhibits some effects of ANG II on neonatal rat cardiac myocytes and suggest that atRA may be a therapeutic candidate for the prevention and therapy of cardiac hypertrophy and remodeling.

cardiac hypertrophy; dedifferentiation; intracellular calcium; hyperplasia, induction of myocyte differentiation


This article has been cited by other articles:


Home page
 J CARDIOVASC PHARMACOL THERHome page
A. Baraka, M. Mikhail, A. Guemei, and S. El Ghotny
Effect of Targeting Mitogen-Activated Protein Kinase on Cardiac Remodeling in Rats
Journal of Cardiovascular Pharmacology and Therapeutics, December 1, 2009; 14(4): 339 - 346.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. Choudhary, A. Palm-Leis, R. C. Scott III, R. S. Guleria, E. Rachut, K. M. Baker, and J. Pan
All-trans retinoic acid prevents development of cardiac remodeling in aortic banded rats by inhibiting the renin-angiotensin system
Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H633 - H644.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. S. Maier
Vitamin A for the heart: progress for cardiac hypertrophy regression?
Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H588 - H589.
[Full Text] [PDF]

Home page
 J. Cell Sci.Home page
L.-L. Yao, Y.-G. Wang, W.-J. Cai, T. Yao, and Y.-C. Zhu
Survivin mediates the anti-apoptotic effect of {delta}-opioid receptor stimulation in cardiomyocytes
J. Cell Sci., March 1, 2007; 120(5): 895 - 907.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. A. R. Paiva, L. S. Matsubara, B. B. Matsubara, M. F. Minicucci, P. S. Azevedo, A. O. Campana, and L. A. M. Zornoff
Retinoic Acid Supplementation Attenuates Ventricular Remodeling after Myocardial Infarction in Rats
J. Nutr., October 1, 2005; 135(10): 2326 - 2328.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Palm-Leis, U. S. Singh, B. S. Herbelin, G. D. Olsovsky, K. M. Baker, and J. Pan
Mitogen-activated Protein Kinases and Mitogen-activated Protein Kinase Phosphatases Mediate the Inhibitory Effects of All-trans Retinoic Acid on the Hypertrophic Growth of Cardiomyocytes
J. Biol. Chem., December 24, 2004; 279(52): 54905 - 54917.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
S. E Hardt and J. Sadoshima
Negative regulators of cardiac hypertrophy
Cardiovasc Res, August 15, 2004; 63(3): 500 - 509.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. Lu, T. Yao, Y.-Z. Zhu, G.-Y. Huang, Y.-X. Cao, and Y.-C. Zhu
Chronic all-trans retinoic acid treatment prevents medial thickening of intramyocardial and intrarenal arteries in spontaneously hypertensive rats
Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1370 - H1377.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. A. R. de Paiva, L. A. M. Zornoff, M. P. Okoshi, K. Okoshi, L. S. Matsubara, B. B. Matsubara, A. C. Cicogna, and A. O. Campana
Ventricular remodeling induced by retinoic acid supplementation in adult rats
Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2242 - H2246.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online