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J Appl Physiol 92: 1978-1986, 2002; doi:10.1152/japplphysiol.00483.2001
8750-7587/02 $5.00
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Vol. 92, Issue 5, 1978-1986, May 2002

Effects of muscle activation on fatigue and metabolism in human skeletal muscle

David W. Russ1, Krista Vandenborne2, Glenn A. Walter3, Mark Elliott4, and Stuart A. Binder-Macleod1,5

1 Graduate Program in Biomechanics and Movement Sciences, University of Delaware, Newark, Delaware 19716; 2 Department of Physical Therapy and 3 Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida 32611; 4 Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19014; and 5 Department of Physical Therapy, University of Delaware, Newark, Delaware 19716

Increasing stimulation frequency has been shown to increase fatigue but not when the changes in force associated with changes in frequency have been controlled. An effect of frequency, independent of force, may be associated with the metabolic cost resulting from the additional activations. Here, two separate experiments were performed on human medial gastrocnemius muscles. The first experiment (n = 8) was designed to test the effect of the number of pulses on fatigue. The declines in force during two repetitive, 150-train stimulation protocols that produced equal initial forces, one using 80-Hz trains and the other using 100-Hz trains, were compared. Despite a difference of 600 pulses (23.5%), the protocols produced similar rates and amounts of fatigue. In the second experiment, designed to test the effect of the number of pulses on the metabolic cost of contraction, 31P-NMR spectra were collected (n = 6) during two ischemic, eight-train stimulation protocols (80- and 100-Hz) that produced comparable forces despite a difference of 320 pulses (24.8%). No differences were found in the changes in Pi concentration, phosphocreatine concentration, and intracellular pH or in the ATP turnover produced by the two trains. These results suggest that the effect of stimulation frequency on fatigue is related to the force produced, rather than to the number of activations. In addition, within the range of frequencies tested, increasing total activations did not increase metabolic cost.

31P-NMR; electrical stimulation; frequency


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