Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
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J Appl Physiol 92: 1970-1977, 2002. First published February 1, 2002; doi:10.1152/japplphysiol.00961.2001
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Vol. 92, Issue 5, 1970-1977, May 2002

Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon

David C. Nieman1, Dru A. Henson1, Steve R. McAnulty1, Lisa McAnulty1, Nathaniel S. Swick1, Alan C. Utter1, Debra M. Vinci1, Shannon J. Opiela1, and Jason D. Morrow2

1 Departments of Health, Leisure, and Exercise Science, and Biology, Appalachian State University, Boone, North Carolina 28608; 2 Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

The purpose of this randomized study was to measure the influence of vitamin C (n = 15 runners) compared with placebo (n = 13 runners) supplementation on oxidative and immune changes in runners competing in an ultramarathon race. During the 7-day period before the race and on race day, subjects ingested in randomized, double-blind fashion 1,500 mg/day vitamin C or placebo. On race day, blood samples were collected 1 h before race, after 32 km of running, and then again immediately after race. Subjects in both groups maintained an intensity of ~75% maximal heart rate throughout the ultramarathon race and ran a mean of 69 km (range: 48-80 km) in 9.8 h (range: 5-12 h). Plasma ascorbic acid was markedly higher in the vitamin C compared with placebo group prerace and rose more strongly in the vitamin C group during the race (postrace: 3.21 ± 0.29 and 1.28 ± 0.12 µg/100 µl, respectively, P < 0.001). No significant group or interaction effects were measured for lipid hydroperoxide, F2-isoprostane, immune cell counts, plasma interleukin (IL)-6, IL-10, IL-1-receptor antagonist, or IL-8 concentrations, or mitogen-stimulated lymphocyte proliferation and IL-2 and IFN-gamma production. These data indicate that vitamin C supplementation in carbohydrate-fed runners does not serve as a countermeasure to oxidative and immune changes during or after a competitive ultramarathon race.

interleukins; ascorbic acid; lymphocytes; isoprostanes; lipid hydroperoxide


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