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J Appl Physiol 92: 1817-1827, 2002. First published December 21, 2001; doi:10.1152/japplphysiol.00675.2001
8750-7587/02 $5.00
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Vol. 92, Issue 5, 1817-1827, May 2002

Correlation properties of tidal volume and end-tidal O2 and CO2 concentrations in healthy infants

Mateja Cernelc1, Béla Suki2, Benjamin Reinmann1, Graham L. Hall1, and Urs Frey1

1 Department of Pediatrics, University Hospital of Berne, CH-3010 Switzerland; and 2 Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215

We investigated whether breath-to-breath fluctuations in tidal volume (VT) and end-tidal O2 and CO2 exhibit long-range correlations and whether parameters describing the correlations can be used as noninvasive descriptors of control of breathing. We measured VT and end-tidal O2 and CO2 over n = 352 ± 104 breaths in 26 term, healthy, unsedated infants (mean age ± SD: 36 ± 6 days) and calculated the detrended fluctuation function [F(n)]. The F(n) of the breath-to-breath time series of VT, O2, and CO2 revealed a linear increase with a breath number on log-log plots with a slope that was significantly different from 0.5 (random) and thus consistent with scale-invariant behavior. Long-range correlations were stronger for O2 than for VT and CO2. The F(n) of many individual signals exhibited a crossover behavior indicating that control mechanisms regulating fluctuations of VT, O2, and CO2 may be different on different time scales. Thus breathing has a memory up to at least 400 breaths that can be characterized by the simple indicator alpha .

control of breathing; lung; airway; long-range correlation


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