Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 92: 1635-1641, 2002; doi:10.1152/japplphysiol.00981.2001
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (5)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hayes, S. G.
Right arrow Articles by Kaufman, M. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hayes, S. G.
Right arrow Articles by Kaufman, M. P.
Vol. 92, Issue 4, 1635-1641, April 2002

Estrogen attenuates the cardiovascular and ventilatory responses to central command in cats

Shawn G. Hayes, Nicolas B. Moya Del Pino, and Marc P. Kaufman

Division of Cardiovascular Medicine, Departments of Internal Medicine and Human Physiology, University of California, Davis, California 95616

Static exercise is well known to increase heart rate, arterial blood pressure, and ventilation. These increases appear to be less in women than in men, a difference that has been attributed to an effect of estrogen on neuronal function. In decerebrate male cats, we examined the effect of estrogen (17beta -estradiol; 0.001, 0.01, 0.1, and 1.0 µg/kg iv) on the cardiovascular and ventilatory responses to central command and the exercise pressor reflex, the two neural mechanisms responsible for evoking the autonomic and ventilatory responses to exercise. We found that 17beta -estradiol, in each of the three doses tested, attenuated the pressor, cardioaccelerator, and phrenic nerve responses to electrical stimulation of the mesencephalic locomotor region (i.e., central command). In contrast, none of the doses of 17beta -estradiol had any effect on the pressor, cardioaccelerator, and ventilatory responses to static contraction or stretch of the triceps surae muscles. We conclude that, in decerebrate male cats, estrogen injected intravenously attenuates cardiovascular and ventilatory responses to central command but has no effect on responses to the exercise pressor reflex.

exercise pressor reflex; heart rate; arterial blood pressure; tendon stretch; muscle afferents


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
S. W. Wong, D. S. Kimmerly, N. Masse, R. S. Menon, D. F. Cechetto, and J. K. Shoemaker
Sex differences in forebrain and cardiovagal responses at the onset of isometric handgrip exercise: a retrospective fMRI study
J Appl Physiol, October 1, 2007; 103(4): 1402 - 1411.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Morelli, M. S. Badr, and J. H. Mateika
Ventilatory responses to carbon dioxide at low and high levels of oxygen are elevated after episodic hypoxia in men compared with women
J Appl Physiol, November 1, 2004; 97(5): 1673 - 1680.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. M. Schmitt and M. P. Kaufman
Estrogen attenuates the exercise pressor reflex in female cats
J Appl Physiol, October 1, 2003; 95(4): 1418 - 1424.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. M. Schmitt and M. P. Kaufman
High concentrations of 17beta -estradiol attenuate the exercise pressor reflex in male cats
J Appl Physiol, April 1, 2003; 94(4): 1431 - 1436.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online