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Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226
The pre-Bötzinger complex (PBC)
is postulated as the center of respiratory rhythmogenesis. Previously,
we found a reduction or plateau of cytochrome oxidase (CO) activity in
the PBC and other respiratory nuclei at postnatal days
3-4, despite a general increase of CO with age, suggesting a
period of synaptic readjustment. The present study examined the
expression of CO and a number of neurochemicals in the PBC at closer
time intervals. At postnatal days 3-4 and, more
prominently, at postnatal day 12, expression of CO,
glutamate, and N-methyl-D-aspartate receptor
subunit 1 was reduced, whereas expression of GABA, GABAB
receptor, glycine receptor, and
-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit
2 was increased. These findings are consistent with our hypothesis that
decreased CO activity is associated with an increase in inhibitory
drive (mediated by GABA and glycine, their receptors, and possibly
blockage of Ca2+ entry by glutamate receptor subunit 2) and
a decrease in excitatory drive (mediated by glutamate and its
receptors). Our findings point to two critical periods during postnatal
development of the rat when their respiratory system may be more
vulnerable to respiratory insults.
N-methyl-D-aspartate receptor subunit 1; glutamate receptor subunit 2; GABAB receptor; neurokinin-1 receptor; glutamate
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