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J Appl Physiol 92: 1339-1347, 2002; doi:10.1152/japplphysiol.00834.2001
8750-7587/02 $5.00
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Vol. 92, Issue 3, 1339-1347, March 2002

HIGHLIGHTED TOPICS
Functional Genomics of Sleep and Circadian Rhythm
Invited Review: Genetic dissection of sleep

Mehdi Tafti1 and Paul Franken2

1 Biochemistry and Clinical Neurophysiology Unit, Department of Psychiatry, University of Geneva, CH-1225 Geneva, Switzerland; and 2 Department of Biological Sciences, Stanford University, Stanford, California 94305

Recent advances in genomics open up new avenues in the analysis of complex behaviors such as sleep. In this analysis, the mouse is the model species of choice because it is amenable to high throughput phenotype and genotype analysis. With the use of the mouse model, unprecedented progress in our understanding of sleep physiology and the treatment of sleep disorders is awaited. This review is intended to provide an overview of available methods and techniques for genetic dissection of sleep in mice. Limits and advantages of different approaches are discussed to highlight the necessity for combining methods to avoid erroneous interpretations. The gap between understanding mechanisms of sleep and its functions may be bridged by finding its molecular bases.

quantitative trait loci; quantitative trait nucleotides; mutagenesis; transgenic mice; gene knockout; gene expression profiling; gene translation regulation


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