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J Appl Physiol 92: 1300-1309, 2002; doi:10.1152/japplphysiol.00030.2001
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Vol. 92, Issue 3, 1300-1309, March 2002

Effect of exercise training at different intensities on fat metabolism of obese men

Dorien P. C. Van Aggel-Leijssen, Wim H. M. Saris, Anton J. M. Wagenmakers, Joan M. Senden, and Marleen A. Van Baak

Department of Human Biology, Nutrition, Toxicology, and Environmental Research Institute, Maastricht University, 6200 MD Maastricht, The Netherlands

The present study investigated the effect of exercise training at different intensities on fat oxidation in obese men. Twenty-four healthy male obese subjects were randomly divided in either a low- [40% maximal oxygen consumption (VO2 max)] or high-intensity exercise training program (70% VO2 max) for 12 wk, or a nonexercising control group. Before and after the intervention, measurements of fat metabolism at rest and during exercise were performed by using indirect calorimetry, [U-13C]palmitate, and [1,2-13C]acetate. Furthermore, body composition and maximal aerobic capacity were measured. Total fat oxidation did not change at rest in any group. During exercise, after low-intensity exercise training, fat oxidation was increased by 40% (P < 0.05) because of an increased non-plasma fatty acid oxidation (P < 0.05). High-intensity exercise training did not affect total fat oxidation during exercise. Changes in fat oxidation were not significantly different among groups. It was concluded that low-intensity exercise training in obese subjects seemed to increase fat oxidation during exercise but not at rest. No effect of high-intensity exercise training on fat oxidation could be shown.

low intensity; stable isotopes; acetate correction factor; [13C]palmitate


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