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Department of Human Biology, Nutrition, Toxicology, and Environmental Research Institute, Maastricht University, 6200 MD Maastricht, The Netherlands
The present
study investigated the effect of exercise training at different
intensities on fat oxidation in obese men. Twenty-four healthy male
obese subjects were randomly divided in either a low- [40% maximal
oxygen consumption (
O2 max)] or
high-intensity exercise training program (70%
O2 max) for 12 wk, or a nonexercising
control group. Before and after the intervention, measurements of fat
metabolism at rest and during exercise were performed by using indirect
calorimetry, [U-13C]palmitate, and
[1,2-13C]acetate. Furthermore, body composition and
maximal aerobic capacity were measured. Total fat oxidation did not
change at rest in any group. During exercise, after low-intensity
exercise training, fat oxidation was increased by 40%
(P < 0.05) because of an increased non-plasma fatty
acid oxidation (P < 0.05). High-intensity exercise training did not affect total fat oxidation during exercise. Changes in
fat oxidation were not significantly different among groups. It was
concluded that low-intensity exercise training in obese subjects seemed
to increase fat oxidation during exercise but not at rest. No effect of
high-intensity exercise training on fat oxidation could be shown.
low intensity; stable isotopes; acetate correction factor; [13C]palmitate
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