Journal of Applied Physiology
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J Appl Physiol 92: 1183-1190, 2002. First published October 26, 2001; doi:10.1152/japplphysiol.00845.2001
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Vol. 92, Issue 3, 1183-1190, March 2002

Pulmonary capillaries are recruited during pulsatile flow

Robert G. Presson Jr.1, William A. Baumgartner Jr.1, Amanda J. Peterson1, Robb W. Glenny4, and Wiltz W. Wagner Jr.1,2,3

Departments of 1 Anesthesiology, 2 Cellular and Integrative Physiology, and 3 Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202-5200; and 4 Departments of Medicine, Physiology, and Biophysics, School of Medicine, University of Washington, Seattle, Washington 98195

Capillaries recruit when pulmonary arterial pressure rises. The duration of increased pressure imposed in such experiments is usually on the order of minutes, although recent work shows that the recruitment response can occur in <4 s. In the present study, we investigate whether the brief pressure rise during cardiac systole can also cause recruitment and whether the recruitment is maintained during diastole. To study these basic aspects of pulmonary capillary hemodynamics, isolated dog lungs were pump perfused alternately by steady flow and pulsatile flow with the mean arterial and left atrial pressures held constant. Several direct measurements of capillary recruitment were made with videomicroscopy. The total number and total length of perfused capillaries increased significantly during pulsatile flow by 94 and 105%, respectively. Of the newly recruited capillaries, 92% were perfused by red blood cells throughout the pulsatile cycle. These data provide the first direct account of how the pulmonary capillaries respond to pulsatile flow by showing that capillaries are recruited during the systolic pulse and that, once open, the capillaries remain open throughout the pulsatile cycle.

pulmonary microcirculation; capillary transit time; videomicroscopy; microspheres; dog


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