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J Appl Physiol 92: 1125-1132, 2002. First published October 26, 2001; doi:10.1152/japplphysiol.00296.2001
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Vol. 92, Issue 3, 1125-1132, March 2002

Gender differences in glucose kinetics and substrate oxidation during exercise near the lactate threshold

Brent C. Ruby1, Andrew R. Coggan2, and Ted W. Zderic1

1 Human Performance Laboratory, University of Montana, Missoula, Montana 59812-1825; and 2 Division of Gerontology, University of Maryland School of Medicine and Geriatric Research, Education, and Clinical Center, Baltimore Veterans Affairs Medical Center, Baltimore, Maryland 21201

The purpose of this investigation was to determine plasma glucose kinetics and substrate oxidation in men and women during exercise relative to the lactate threshold (LT). Subjects cycled for 25 min at 70 and 90% of O2 uptake (VO2) at LT (70 and 90% LT, respectively). Plasma glucose appearance (Ra) and disappearance (Rd) were determined with a primed constant infusion of [6,6-2H]glucose. There were no significant differences in glucose Ra between men [22.6 ± 1.9 and 39.9 ± 3.9 µmol · kg fat-free mass (FFM)-1 · min-1 for 70 and 90% LT, respectively] and women (22.3 ± 2.7 and 33.9 ± 5.7 µmol · kg FFM-1 · min-1 for 70 and 90% LT, respectively). Similarly, there were no significant differences in glucose Rd between men (21.2 ± 1.9 and 38.1 ± 3.7 µmol · kg FFM-1 · min-1 for 70 and 90% LT, respectively) and women (21.3 ± 2.8 and 33.3 ± 5.6 µmol · kg FFM-1 · min-1 for 70 and 90% LT, respectively). Although there were no differences between genders in the relative contribution of carbohydrate (CHO) to total energy expenditure, the relative contribution of muscle glycogen to total CHO oxidation (75.8 ± 3.2 and 64.2 ± 8.0% for men and women, respectively, at 70% LT and 75.1 ± 2.6 and 60.1 ± 11.2% for men and women, respectively, at 90% LT) was lower in women. Consequently, the relative contribution of blood glucose to total CHO oxidation was significantly higher in women. These results indicate that although plasma glucose Ra and Rd are similar in men and women, the relative contribution of muscle glycogen and blood glucose is significantly different in women during moderate-intensity exercise relative to LT.

glucose metabolism; luteal phase


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