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Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115
During ozone (O3)
exposure, adult mice decrease their minute ventilation
(
E). To determine whether there are age-related differences in the ventilatory response to O3, A/J mice,
aged 2, 4, 8, or 12 wk, were exposed to O3
(0.3-3.0 parts/million for 3 h) in nose-only exposure
plethysmographs. Baseline E normalized for body
weight (E/g) decreased with increasing age,
consistent with the higher metabolic rates of younger animals.
O3 caused a concentration-related decrease in
E in mice of all ages, but the response was
significantly less in 2-wk-old than in older mice. The increased
baseline E/g and smaller decrements in
E induced by O3 in immature mice
resulted in an inhaled dose of O3 normalized for body
weight that was three to four times higher than in adult mice.
O3 exposure caused a dose-related increase in airway
responsiveness in 8- and 12-wk-old mice but did not cause airway
hyperresponsiveness at any dose in either 2- or 4-wk-old mice, although
higher inhaled doses of O3 normalized for body weight were
delivered to these younger animals. Interleukin-6 and macrophage
inflammatory protein-2 levels in bronchoalveolar lavage fluid were also
increased in 8-wk-old compared with 2-wk-old mice exposed to
O3. The results suggest that immature mice are less
sensitive than adult mice to O3, at least in terms of the ability of O3 to induce airway hyperresponsiveness and
promote release of certain cytokines.
ventilation; ontogeny; bronchoconstriction; tumor necrosis
factor-
; interleukin-6; macrophage inflammatory protein-2; polymorphonuclear leukocytes
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