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Departments of 1 Physiology and 3 Medicine and Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio 78284-7886; and 2 Exercise Physiology and Metabolism Laboratory, Department of Kinesiology and Health Education, University of Texas, Austin, Texas 78712
Exercise training
improves skeletal muscle insulin sensitivity in the obese Zucker rat.
The purpose of this study was to investigate whether the improvement in
insulin action in response to exercise training is associated with
enhanced insulin receptor signaling. Obese Zucker rats were trained for
7 wk and studied by using the hindlimb-perfusion technique 24 h,
96 h, or 7 days after their last exercise training bout.
Insulin-stimulated glucose uptake (traced with 2-deoxyglucose) was
significantly reduced in untrained obese Zucker rats compared with lean
controls (2.2 ± 0.17 vs. 5.4 ± 0.46 µmol · g
1 · h1). Glucose
uptake was normalized 24 h after the last exercise bout (4.9 ± 0.41 µmol · g1 · h1)
and remained significantly elevated above the untrained obese Zucker
rats for 7 days. However, exercise training did not increase insulin
receptor or insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation, phosphatidylinositol 3-kinase (PI3-kinase) activity associated with IRS-1 or tyrosine phosphorylated immunoprecipitates, or
Akt serine phosphorylation. These results are consistent with the hypothesis that, in obese Zucker rats, adaptations occur during training that lead to improved insulin-stimulated muscle glucose uptake
without affecting insulin receptor signaling through the PI3-kinase pathway.
phosphatidylinositol 3-kinase; insulin receptor substrate-1; glucose uptake; tyrosine phosphorylation
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