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J Appl Physiol 92: 622-626, 2002; doi:10.1152/japplphysiol.00574.2001
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Vol. 92, Issue 2, 622-626, February 2002

Similar ventilation distribution in normal subjects prone and supine during tidal breathing

M. J. Rodríguez-Nieto1, G. Peces-Barba1, N. González Mangado1, M. Paiva2, and S. Verbanck3

1 Laboratorio de Fisiopatología Respiratoria, Fundación Jiménez Díaz, Madrid 28040, Spain; 2 Laboratoire de Physique Biomédicale, Université Libre de Bruxelles, 1070 Brussels; and 3 Respiratory Division, Academic Hospital, Vrije Universiteit Brussel, 1090 Brussels, Belgium

Multiple-breath washout (MBW) tests, with end-expiratory lung volume at functional residual capacity (FRC) and 90% O2, 5% He, and 5% SF6 as an inspired gas mixture, were performed in healthy volunteers in supine and prone postures. The semilog plot of MBW N2 concentrations was evaluated in terms of its curvilinearity. The MBW N2 normalized slope analysis yielded indexes of acinar and conductive ventilation heterogeneity (Verbanck S, Schuermans D, Van Muylem A, Paiva M, Noppen M, and Vincken W. J App Physiol 83: 1907-1916, 1997). Also, the difference between SF6 and He normalized phase III slopes was computed in the first MBW expiration. Only MBW tests with similar FRC in the prone and supine postures (P > 0.1; n = 8) were considered. Prone and supine postures did not reveal any significant differences in curvilinearity, N2 normalized slope-derived indexes of conductive or acinar ventilation heterogeneity, nor SF6-He normalized phase III slope difference in the first MBW expiration (P > 0.1 for all). The absence of significant changes in any of the MBW indexes suggests that ventilation heterogeneity is similar in the supine and prone postures of normal subjects breathing near FRC.

ventilation heterogeneity; tidal breathing; posture; phase III slope


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