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J Appl Physiol 92: 617-621, 2002. First published October 5, 2001; doi:10.1152/japplphysiol.00891.2001
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Vol. 92, Issue 2, 617-621, February 2002

Measurement of nasal patency in anesthetized and conscious dogs

Michael C. Koss1, Yongxin Yu1, John A. Hey2, and Robbie L. McLeod2

1 Department of Cell Biology, University of Oklahoma, College of Medicine, Oklahoma City, Oklahoma 73190; and 2 Allergy, Schering-Plough Research Institute, Kenilworth, New Jersey 07033

Experiments were undertaken to characterize a noninvasive chronic, model of nasal congestion in which nasal patency is measured using acoustic rhinometry. Compound 48/80 was administered intranasally to elicit nasal congestion in five beagle dogs either by syringe (0.5 ml) in thiopental sodium-anesthetized animals or as a mist (0.25 ml) in the same animals in the conscious state. Effects of mast cell degranulation on nasal cavity volume as well as on minimal cross-sectional area (Amin) and intranasal distance to Amin (Dmin) were studied. Compound 48/80 caused a dose-related decrease in nasal cavity volume and Amin together with a variable increase in Dmin. Maximal responses were seen at 90-120 min. Compound 48/80 was less effective in producing nasal congestion in conscious animals, which also had significantly larger basal nasal cavity volumes. These results demonstrate the utility of using acoustic rhinometry to measure parameters of nasal patency in dogs and suggest that this model may prove useful in studies of the actions of decongestant drugs.

methods; nasal congestion; Compound 48/80; nasal airway volume; minimal cross-sectional distance to minimal cross-sectional area


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