Journal of Applied Physiology
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J Appl Physiol 92: 609-616, 2002; doi:10.1152/japplphysiol.00186.2001
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Vol. 92, Issue 2, 609-616, February 2002

Oxygen uptake kinetics for moderate exercise are speeded in older humans by prior heavy exercise

Barry W. Scheuermann1,2, Chris Bell1, Donald H. Paterson1, Thomas J. Barstow2, and John M. Kowalchuk1,3

1 Centre for Activity and Aging, School of Kinesiology and 3 Department of Physiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7; and 2 Department of Kinesiology, Kansas State University, Manhattan, Kansas 66506-0302

This study examined the effect of heavy-intensity warm-up exercise on O2 uptake (VO2) kinetics at the onset of moderate-intensity (80% ventilation threshold), constant-work rate exercise in eight older (65 ± 2 yr) and seven younger adults (26 ± 1 yr). Step increases in work rate from loadless cycling to moderate exercise (Mod1), heavy exercise, and moderate exercise (Mod2) were performed. Each exercise bout was 6 min in duration and separated by 6 min of loadless cycling. VO2 kinetics were modeled from the onset of exercise by use of a two-component exponential model. Heart rate (HR) kinetics were modeled from the onset of exercise using a single exponential model. During Mod1, the time constant (tau ) for the predominant rise in VO2 (tau VO2) was slower (P < 0.05) in the older adults (50 ± 10 s) than in young adults (19 ± 5 s). The older adults demonstrated a speeding (P < 0.05) of VO2 kinetics when moderate-intensity exercise (Mod2) was preceded by high-intensity warm-up exercise (tau VO2, 27 ± 3 s), whereas young adults showed no speeding of VO2 kinetics (tau VO2, 17 ± 3 s). In the older and younger adults, baseline HR preceding Mod2 was elevated compared with Mod1, but the tau  for HR kinetics was slowed (P < 0.05) in Mod2 only for the older adults. Prior heavy-intensity exercise in old, but not young, adults speeded VO2 kinetics during Mod2. Despite slowed HR kinetics in Mod2 in the older adults, an elevated baseline HR before the onset of Mod2 may have led to sufficient muscle perfusion and O2 delivery. These results suggest that, when muscle blood flow and O2 delivery are adequate, muscle O2 consumption in both old and young adults is limited by intracellular processes within the exercising muscle.

aging; heart rate; oxygen transport; oxygen utilization


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