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J Appl Physiol 92: 75-83, 2002;
8750-7587/02 $5.00
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Vol. 92, Issue 1, 75-83, January 2002

Lung function during and after prolonged head-down bed rest

Stéphanie Montmerle, Jonas Spaak, and Dag Linnarsson

Section of Environmental Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden

We determined the effects of prolonged head-down tilt bed rest (HDT) on lung mechanics and gas exchange. Six subjects were studied in supine and upright postures before (control), during [day 113 (D113)], and after (R + number of days of recovery) 120 days of HDT. Peak expiratory flow (PF) never differed between positions at any time and never differed from controls. Maximal midexpiratory flow (FEF25-75%) was lower in the supine than in the upright posture before HDT and was reduced in the supine posture by about 20% between baseline and D113, R + 0, and R + 3. The diffusing capacity for carbon monoxide corrected to a standardized alveolar volume (volume-corrected DLCO) was lower in the upright than in the supine posture and decreased in both postures by 20% between baseline and R + 0 and by 15% between baseline and R + 15. Pulmonary blood flow (QC) increased from R + 0 to R + 3 by 20 (supine) and 35% (upright). As PF is mostly effort dependent, our data speak against major respiratory muscle deconditioning after 120 days of HDT. The decrease in FEF25-75% suggests a reduction in elastic recoil. Time courses of volume-corrected DLCO and QC could be explained by a decrease in central blood volume during and immediately after HDT.

head-down tilt; hypokinesia; dynamic spirometry; lung diffusing capacity; lung perfusion


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