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J Appl Physiol 92: 418-423, 2002;
8750-7587/02 $5.00
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Vol. 92, Issue 1, 418-423, January 2002

HIGHLIGHTED TOPICS
Functional Genomics of Sleep and Circadian Rhythm
Selected Contribution: Influence of genioglossus tonic activity on upper airway dynamics assessed by phrenic nerve stimulation

F. Sériès and I. Marc

Centre de Recherche, Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l'Université Laval, Québec, Canada G1V 4G5

Upper airway (UA) dynamics can be evaluated during wakefulness by using electrical phrenic nerve stimulation (EPNS) applied at end-expiration during exclusive nasal breathing by dissociating twitch flow and phasic activation of UA muscles. This technique can be used to quantify the influence of nonphasic electromyographic (EMG) activity on UA dynamics. UA dynamics was characterized by using EPNS when increasing tonic EMG activity with CO2 stimulation in six normal awake subjects. Instantaneous flow, esophageal and nasopharyngeal pressures, and genioglossal EMG activity were recorded during EPNS at baseline and during CO2 ventilatory stimulation. The proportion of twitches presenting an inspiratory-flow limitation pattern decreased from 100% at baseline to 78.7 ± 21.4% (P = 10-4) during CO2 rebreathing. During CO2 stimuli, maximal inspiratory twitch flow (VImax) of flow-limited twitches significantly rose, with the driving pressure at which flow limitation occurred being more negative. For the group as a whole, the increase in VImax and the decrease in pressure were significantly correlated with the rise in end-expiratory EMG activity. UA stability assessed by EPNS is dramatically modified during CO2 ventilatory stimulation. Changes in tonic genioglossus EMG activity significantly contribute to the improvement in UA stability.

electromyographic tonic activity; diaphragm twitch; electrical phrenic nerve stimulation


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