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1 Department of Kinesiology and Applied Physiology, and 2 Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado 80309
10.1152/ japplphysiol.00832.2001.
To examine the effects of gene
inactivation on the plasticity of skeletal muscle, mice null for a
specific myosin heavy chain (MHC) isoform were subjected to a voluntary
wheel-running paradigm. Despite reduced running performance compared
with nontransgenic C57BL/6 mice (NTG), both MHC IIb and MHC IId/x null
animals exhibited increased muscle fiber size and muscle oxidative
capacity with wheel running. In the MHC IIb null animals, there was no
significant change in the percentage of muscle fibers expressing a
particular MHC isoform with voluntary wheel running at any time point.
In MHC IId/x null mice, wheel running produced a significant increase
in the percentage of fibers expressing MHC IIa and MHC I and a
significant decrease in the percentage of fibers expressing MHC IIb.
Muscle pathology was not affected by wheel running for either MHC null
strain. In summary, despite their phenotypes, MHC null mice do engage in voluntary wheel running. Although this wheel-running activity is
lessened compared with NTG, there is evidence of distinct patterns of
muscle adaptation in both null strains.
myosin heavy chain; endurance exercise; muscle plasticity
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