Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 92: 18-24, 2002;
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Spangenburg, E. E.
Right arrow Articles by Williams, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Spangenburg, E. E.
Right arrow Articles by Williams, J. H.
Vol. 92, Issue 1, 18-24, January 2002

Effects of moderate heart failure and functional overload on rat plantaris muscle

Espen E. Spangenburg1, Simon J. Lees1, Jeff S. Otis1, Timothy I. Musch2, Robert J. Talmadge1, and Jay H. Williams1

1 Muscular Function Laboratory, Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061; and 2 Departments of Kinesiology and Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506

It is thought that changes in sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) of skeletal muscle contribute to alterations in skeletal muscle function during congestive heart failure (CHF). It is well established that exercise training can improve muscle function. However, it is unclear whether similar adaptations will result from exercise training in a CHF patient. Therefore, the purpose of this study was to determine whether skeletal muscle during moderate CHF adapts to increased activity, utilizing the functional overload (FO) model. Significant increases in plantaris mass of the CHF-FO and sham-FO groups compared with the CHF and control (sham) groups were observed. Ca2+ uptake rates were significantly elevated in the CHF group compared with all other groups. No differences were detected in Ca2+ uptake rates between the CHF-FO, sham, and sham-FO groups. Increases in Ca2+ uptake rates in moderate-CHF rats were not due to changes in SERCA isoform proportions; however, FO may have attenuated the CHF-induced increases through alterations in SERCA isoform expression. Therefore, changes in skeletal muscle Ca2+ handling during moderate CHF may be due to alterations in regulatory mechanisms, which exercise may override, by possibly altering SERCA isoform expression.

calcium-adenosinetriphosophatase; hypertrophy; sarcoplasmic reticulum; chronic heart failure


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
H.-M. S. Thorud, E. Verburg, P. K. Lunde, T. A. Stromme, I. Sjaastad, and O. M. Sejersted
Temperature-dependent skeletal muscle dysfunction in rats with congestive heart failure
J Appl Physiol, October 1, 2005; 99(4): 1500 - 1507.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
E. De Sousa, P. Lechene, D. Fortin, B. N'Guessan, S. Belmadani, X. Bigard, V. Veksler, and R. Ventura-Clapier
Cardiac and skeletal muscle energy metabolism in heart failure: beneficial effects of voluntary activity
Cardiovasc Res, November 1, 2002; 56(2): 260 - 268.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. W. Booth, M. V. Chakravarthy, S. E. Gordon, and E. E. Spangenburg
Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy
J Appl Physiol, July 1, 2002; 93(1): 3 - 30.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online