Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol 92: 13-17, 2002;
8750-7587/02 $5.00
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Vol. 92, Issue 1, 13-17, January 2002

Blood pressure and mesenteric resistance arterial function after spaceflight

Daniel C. Hatton1,2, Qi Yue1, Justin Chapman1, Hong Xue1, Jacqueline Dierickx2, Chantal Roullet1, Sarah Coste2, Jean Baptiste Roullet1, and David A. McCarron1

Departments of 1 Nephrology, Hypertension, and Clinical Pharmacology and 2 Behavioral Neuroscience, Oregon Health Sciences University, Portland, Oregon 97201

Ground studies indicate that spaceflight may diminish vascular contraction. To examine that possibility, vascular function was measured in spontaneously hypertensive rats immediately after an 18-day shuttle flight. Isolated mesenteric resistance arterial responses to cumulative additions of norepinephrine, acetylcholine, and sodium nitroprusside were measured using wire myography within 17 h of landing. After flight, maximal contraction to norepinephrine was attenuated (P < 0.001) as was relaxation to acetylcholine (P < 0.001) and sodium nitroprusside (P < 0.05). At high concentrations, acetylcholine caused vascular contraction in vessels from flight animals but not in vessels from vivarium control animals (P < 0.05). The results are consistent with data from ground studies and indicate that spaceflight causes both endothelial-dependent and endothelial-independent alterations in vascular function. The resulting decrement in vascular function may contribute to orthostatic intolerance after spaceflight.

spontaneously hypertensive rats; microgravity; vascular contraction; vascular relaxation


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