Journal of Applied Physiology Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 91: 2816-2822, 2001;
8750-7587/01 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (33)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harada, H.
Right arrow Articles by Grisham, M. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harada, H.
Right arrow Articles by Grisham, M. B.
Vol. 91, Issue 6, 2816-2822, December 2001

HIGHLIGHTED TOPICS
Genome and Hormones: Gender Differences in Physiology
Selected Contribution: Effects of gender on reduced-size liver ischemia and reperfusion injury

Hirohisa Harada1,*, Kevin P. Pavlick1,*, Ian N. Hines1, Jason M. Hoffman1, Sulaiman Bharwani2, Laura Gray1, Robert E. Wolf2, and Matthew B. Grisham1

1 Department of Molecular and Cellular Physiology and 2 Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130

Hepatic resection with concomitant periods of ischemia and reperfusion (I/R) is a common occurrence in resectional surgery as well as reduced-size liver transplantation (e.g., split liver or living donor transplantation). However, the I/R induced by these types of surgical manipulations may impair liver regeneration, ultimately leading to liver failure. The objectives of the study were to develop a murine model of reduced-size liver I/R and assess the role of gender in this model of hepatocellular injury. We found that 100% of female mice survived the surgery indefinitely, whereas all male mice had greater initial liver injury and died within 5 days after surgery. The protective effect observed in females appeared to be due to ovarian 17beta -estradiol, as ovariectomy of females or administration of a selective estrogen antagonist to female mice resulted in enhanced liver injury and greater mortality following reduced-size liver I/R. Conversely, 17beta -estradiol-treated male mice exhibited less hepatocellular damage and survived indefinitely. Taken together, these data demonstrate an estrogen-mediated protective pathway(s) that limits or attenuates hepatocellular injury induced by reduced-size liver I/R.

inflammation; estrogen; ovariectomy; nitric oxide; reactive oxygen species

* H. Harada and K. P. Pavlick contributed equally to the study and to the preparation of the manuscript.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
Rebuttal from Drs. Tiidus and Enns
J Appl Physiol, March 1, 2009; 106(3): 1014 - 1014.
[Full Text] [PDF]

Home page
 Arch SurgHome page
Y. Yokoyama, M. Nagino, K. Oda, H. Nishio, T. Ebata, T. Abe, T. Igami, and Y. Nimura
Sex Dimorphism in the Outcome of Preoperative Right Portal Vein Embolization
Arch Surg, March 1, 2008; 143(3): 254 - 259.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. L. Enns and P. M. Tiidus
Estrogen influences satellite cell activation and proliferation following downhill running in rats
J Appl Physiol, February 1, 2008; 104(2): 347 - 353.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
L. O. Conzelmann, I. N. Hines, M. Kremer, A. W. Perry, J. J. Lemasters, and M. D. Wheeler
Extrahepatic Cells Contribute to the Progenitor/Stem Cell Response Following Reduced-Size Liver Transplantation in Mice
Experimental Biology and Medicine, April 1, 2007; 232(4): 571 - 580.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol Ind HealthHome page
P Mussali-Galante, M. Avila-Costa, G Pinon-Zarate, G Martinez-Levy, V Rodriguez-Lara, M Rojas-Lemus, M. Avila-Casado, and T. Fortoul
DNA damage as an early biomarker of effect in human health
Toxicology and Industrial Health, June 1, 2005; 21(5-6): 155 - 166.
[Abstract] [PDF]

Home page
 Br. J. Sports. Med.Home page
P M Tiidus
Can oestrogen influence skeletal muscle damage, inflammation, and repair?
Br. J. Sports Med., May 1, 2005; 39(5): 251 - 253.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
Z. F. Ba, T. Shimizu, L. Szalay, K. I. Bland, and I. H. Chaudry
Gender differences in small intestinal perfusion following trauma hemorrhage: the role of endothelin-1
Am J Physiol Gastrointest Liver Physiol, May 1, 2005; 288(5): G860 - G865.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
Z. F. Ba, Y. Yokoyama, B. Toth, L. W. Rue III, K. I. Bland, and I. H. Chaudry
Gender differences in small intestinal endothelial function: inhibitory role of androgens
Am J Physiol Gastrointest Liver Physiol, March 1, 2004; 286(3): G452 - G457.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
B. Toth, Y. Yokoyama, J. F. Kuebler, M. G. Schwacha, L. W. Rue III, K. I. Bland, and I. H. Chaudry
Sex Differences in Hepatic Heme Oxygenase Expression and Activity Following Trauma and Hemorrhagic Shock
Arch Surg, December 1, 2003; 138(12): 1375 - 1382.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Harada, K. P. Pavlick, I. N. Hines, D. J. Lefer, J. M. Hoffman, S. Bharwani, R. E. Wolf, and M. B. Grisham
Sexual dimorphism in reduced-size liver ischemia and reperfusion injury in mice: Role of endothelial cell nitric oxide synthase
PNAS, January 21, 2003; 100(2): 739 - 744.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online