Vol. 91, Issue 6, 2776-2784, December 2001
HIGHLIGHTED TOPICS
Genome and Hormones: Gender Differences in Physiology
Invited Review: Pharmacogenetics of estrogen replacement
therapy
David M.
Herrington and
Karen Potvin
Klein
Department of Internal Medicine/Cardiology, Wake Forest
University School of Medicine, Winston-Salem, North Carolina 27157
There
are a number of genetic factors that likely modulate both the
beneficial and adverse effects of estrogen. An important domain
of consideration is the relationship of estrogen and thrombosis risk.
Gene polymorphisms among the key elements of the coagulation and
fibrinolytic cascade appear to influence the effects of estrogen on
risk for venous thromboembolic events and possibly arterial thrombosis as well. Emerging data also suggest that allelic variants in
the estrogen receptor-
may modulate estrogen's effects,
especially with respect to bone and lipid metabolism.
estrogen receptor-; polymorphisms; postmenopausal women; thrombosis; risk factors
