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increases lung tissue hysteresivity
in transgenic mice
1 TVW Telethon Institute for Child Health Research, West Perth 6872; 2 King Edward and Princess Margaret Hospital, Perth 6840; 4 Department of Paediatrics, University of Western Australia, Subiaco 6008, WA, Australia; and 3 Division of Pulmonary Biology, Children's Hospital Medical Centre, Cincinnati, Ohio 45229-3039
Increased transforming growth factor (TGF)-
has been observed in neonatal chronic lung disease. Lungs of transgenic
mice that overexpress TGF- develop enlarged air spaces and pulmonary fibrosis compared with wild-type mice. We hypothesized that these pathological changes may alter the mechanical coupling of viscous and
elastic forces within lung parenchyma. Respiratory impedance was
measured in open-chested, tracheostomized adult wild-type and TGF-
mice by using the forced oscillation technique (0.25-19.63 Hz)
delivered by flexiVent (Scireq, Montreal, PQ). Estimates of airway
resistance (Raw), inertance (I), and the coefficients of tissue damping
(GL) and tissue elastance (HL) were
obtained by fitting a model to each impedance spectrum. Hysteresivity
(
) was calculated as GL/HL. There
was a significant increase in (P < 0.01) and a
trend to a decrease in HL (P = 0.07) of TGF- mice compared with the wild-type group. There was no
significant change in Raw, I, or GL. Structural abnormality
present in the lungs of adult TGF- mice alters viscoelastic coupling
of the tissues, as evidenced by a change in .
pulmonary fibrosis; respiratory mechanics; forced oscillation
technique; transforming growth factor-
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