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J Appl Physiol 91: 2517-2522, 2001;
8750-7587/01 $5.00
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Vol. 91, Issue 6, 2517-2522, December 2001

Changes in microvascular fluid filtration capacity during 120 days of 6° head-down tilt

F. Christ1, J. Gamble2, V. Baranov3, A. Kotov3, A. Chouker1, M. Thiel1, I. B. Gartside, C. M. Moser1, J. Abicht1, and K. Messmer4

1 Clinic of Anaesthesiology and 4 Institute of Surgical Research, University of Munich, 81366 Munich, Germany; 2 Department of Paediatrics, Imperial College School of Medicine, London SW10 9NH, Great Britain; and 3 Institute of Biomedical Problems, Moscow 123007, Russia

We used venous congestion strain gauge plethysmography (VCP) to measure the changes in fluid filtration capacity (Kf), isovolumetric venous pressure (Pvi), and blood flow in six volunteers before, on the 118th day (D118) of head-down tilt (HDT), and 2 days after remobilization (Post). We hypothesized that 120 days of HDT cause significant micro- and macrovascular changes. We observed a significant increase in Kf from 3.6 ± 0.4 × 10-3 to 5.7 ± 0.9 × 10-3 ml · min-1 · 100 ml-1 · mmHg-1 (+51.4%; P < 0.003), which returned to pretilt values (4.0 + 0.4 × 10-3 ml · min-1 · 100 ml-1 · mmHg-1) after remobilization. Similarly, Pvi increased from 13.4 ± 2.1 mmHg to 28.9 ± 2.8 mmHg (+105.8%; P < 0.001) at D118 and was not significantly different at Post (12.4 ± 2.6 mmHg). Blood flow decreased significantly from 2.3 ± 0.3 to 1.3 ± 0.2 ml · min-1 · 100 ml tissue-1 at D118 and was found elevated to 3.4 ± 0.7 ml · min-1 · 100 ml tissue-1 at Post. We believe that the increased Kf is caused by a higher microvascular water permeability. Because this may result in edema formation, it could contribute to the alterations in fluid homeostasis after exposure to microgravity.

microgravity; fluid filtration capacity; microvascular permeability; head-down tilt


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