| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Autonomic Reflex Laboratory, Department of Neurology, McGill University, and 2 Division of Nephrology, Lady Davis Institute, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
To test whether cerebral autoregulation is impaired in patients with neurally mediated syncope (NMS), we evaluated 15 normal subjects and 37 patients with recurrent NMS. Blood pressure (BP), heart rate, and cerebral blood velocity (CBV) (transcranial Doppler) were recorded at rest and during 80° head-up tilt (HUT). Static cerebral autoregulation as assessed from the change in cerebrovascular resistance during HUT was the same in NMS and controls. Properties of dynamic cerebral autoregulation were inferred from transfer gain, coherence, and phase of the relationship between BP and CBV estimated from filtered data segments (0.02-0.8 Hz). During the 3 min preceding syncope, dynamic cerebral autoregulation of subjects with NMS did not differ from that of controls nor did it change over the course of HUT in patients with NMS or in control subjects. Dynamic cerebral autoregulation was also unaffected by the degree of orthostatic intolerance as inferred from latency to onset of syncope. We conclude that cerebral autoregulation in patients with recurrent syncope does not differ from that of normal control subjects.
cerebrovascular circulation; Fourier analysis; hemodynamics
This article has been cited by other articles:
|
|
 |
|
  E. L. Sammons, N. J. Samani, S. M. Smith, W. E. Rathbone, S. Bentley, J. F. Potter, and R. B. Panerai Influence of noninvasive peripheral arterial blood pressure measurements on assessment of dynamic cerebral autoregulation J Appl Physiol, July 1, 2007; 103(1): 369 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Zhang and B. D. Levine Autonomic Ganglionic Blockade Does Not Prevent Reduction in Cerebral Blood Flow Velocity During Orthostasis in Humans Stroke, April 1, 2007; 38(4): 1238 - 1244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Cupples and B. Braam Assessment of renal autoregulation Am J Physiol Renal Physiol, April 1, 2007; 292(4): F1105 - F1123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Kolb, D. L. Rotella, and H. M. Stauss Frequency response characteristics of cerebral blood flow autoregulation in rats Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H432 - H438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Mitsis, R. Zhang, B. D. Levine, and V. Z. Marmarelis Cerebral hemodynamics during orthostatic stress assessed by nonlinear modeling J Appl Physiol, July 1, 2006; 101(1): 354 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Panerai, P. J. Eames, and J. F. Potter Multiple coherence of cerebral blood flow velocity in humans Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H251 - H259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Guo, N. Tierney, F. Schaller, P. B. Raven, S. A. Smith, and X. Shi Cerebral autoregulation is preserved during orthostatic stress superimposed with systemic hypotension J Appl Physiol, June 1, 2006; 100(6): 1785 - 1792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A F Folino Cerebral autoregulation in neurally mediated syncope: victim or executioner? Heart, June 1, 2006; 92(6): 724 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Hermosillo, J. L. Jordan, M. Vallejo, A. Kostine, M. F Marquez, and M. Cardenas Cerebrovascular blood flow during the near syncopal phase of head-up tilt test: a comparative study in different types of neurally mediated syncope Europace, March 1, 2006; 8(3): 199 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Schondorf, J. Benoit, and R. Stein Cerebral autoregulation is preserved in postural tachycardia syndrome J Appl Physiol, September 1, 2005; 99(3): 828 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. N Ainslie, J. C Ashmead, K. Ide, B. J Morgan, and M. J Poulin Differential responses to CO2 and sympathetic stimulation in the cerebral and femoral circulations in humans J. Physiol., July 15, 2005; 566(2): 613 - 624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Krishnamurthy, X. Wang, D. Bhakta, E. Bruce, J. Evans, T. Justice, and A. Patwardhan Dynamic cardiorespiratory interaction during head-up tilt-mediated presyncope Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2510 - H2517. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. V. Immink, B.-J. H. van den Born, G. A. van Montfrans, R. P. Koopmans, J. M. Karemaker, and J. J. van Lieshout Impaired Cerebral Autoregulation in Patients With Malignant Hypertension Circulation, October 12, 2004; 110(15): 2241 - 2245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zhang, T. E. Wilson, S. Witkowski, J. Cui, C. G. Crandall, and B. D. Levine Inhibition of nitric oxide synthase does not alter dynamic cerebral autoregulation in humans Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H863 - H869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Brys, C. M. Brown, H. Marthol, R. Franta, and M. J. Hilz Dynamic cerebral autoregulation remains stable during physical challenge in healthy persons Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H1048 - H1054. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Van Lieshout, W. Wieling, J. M. Karemaker, and N. H. Secher Syncope, cerebral perfusion, and oxygenation J Appl Physiol, March 1, 2003; 94(3): 833 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Edwards, J. K. Shoemaker, and R. L. Hughson Dynamic modulation of cerebrovascular resistance as an index of autoregulation under tilt and controlled PETCO2 Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2002; 283(3): R653 - R662. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
